hla-g is normally expressed on human trophoblast cells. it is a non-classical mhc molecule class i b. the role of hla-g in diabetic type 1 is not known. we investigated the role of ifn-β in induction hla-g expression on the monocyte derived dendritic cells (dc) in diabetes type 1. treatment of dendritic cell with ifn-β in vitro from diabetic patients (n=20) and normal subjects (n=20) resulted t...

during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. we investigated the role of ifn-β in induction hla-g expression on the monocyte derived dc and cytokine profile in diabetes type 1. we accomplished secretary pattern and total cytokine production of the th1 cytokine (il-2, γifn) and th2 cyto...

In vivo dendritic-cell targeting constitutes a promising strategy for anticancer vaccination. Here, we discuss the usage of multivalent DC-SIGN-targeting glycan platforms that allow for the efficient routing of antigens to the endo-lysosomal pathway as well as to a yet uncharacterized cross-presentation mechanism inducing CD4+ and CD8+ T-cell responses.

Introduction: Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop ...

Reelin, a glycoprotein of the extracellular matrix, has been focus several studies over years, mostly for its role in cell migration. Here we report this molecule and downstream pathways post-mitotic neurons how they contribute to neural circuit assembly, refinement function. Accumulating evidence pointed at major Reelin axonal guidance, synaptogenesis dendritic spine formation. In particular, ...

Monocytes are one of the major phagocytic cells in the periphery that patrols the circulation for invading pathogens, and upon activation differentiates into dendritic cells, capable of migration to lymph nodes eliciting an adaptive immune response. Monocytes has for more than a decade been precursor cell for generation of autologous dendritic cell cancer vaccines, but clinical results have sho...