Caveolae are flask-shaped plasma membrane subdomains abundant in most cell types that participate in endocytosis. Caveola formation and functions require membrane proteins of the caveolin family, and cytoplasmic proteins of the cavin family. Cationic peptide dendrimers are non-vesicular chemical carriers that can transport pharmacological agents or genetic material across the plasma membrane. W...

A series of novel glycol-clusters containing sulfonated N-acetyl-D-glucosamine (GlcNAc) have been synthesized using click chemistry. Three dendrimers with aromatic dendrons were synthesized using chlorination, azidation and click chemistries. The resulting dendrimers were modified with azide-terminated sulfonated GlcNAc using click chemistry. The sulfonated dendrimers showed affinity for protei...

The synthesis and size-selective catalytic activity of Pd nanoparticles encapsulated within dendrimers functionalized with different-sized end groups is described. We designed and synthesized a series of fourth-generation poly(amidoamine) dendrimers having various extents of steric crowding on their periphery. This was accomplished by reacting the terminal amine groups of these dendrimers with ...

Dendrimers are polybranched and polyfunctionalized tree-like polymers. Unlike linear polymers, they have perfectly defined structure and molecular weight, due to their iterative step-by-step synthesis. Their multivalent structure and supramolecular properties have made them attractive nanotools for applications, particularly in biology and medicine. Among the different biological and medical pr...

the Corrosion inhibition of mild steel in 1 M HCl has been investigated using three dendrimers by means of gravimetric, electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, scanning electron microscopy (SEM) and energy dispersive Xray spectroscopy (EDX) techniques. Results showed that inhibition efficiency increases with increasing concentration of dendrimers. Among the s...

Dendrimers are unique highly branched macromolecules with numerous groundbreaking biomedical applications under development. Here we identified poly(amido amine) (PAMAM) dendrimers as novel blockers for the pore-forming B components of the binary anthrax toxin (PA63) and Clostridium botulinum C2 toxin (C2IIa). These pores are essential for delivery of the enzymatic A components of the internali...

With the aim to make the influence of pentafluorophenyl groups in the periphery of high generation dendrons and dendrimers on their NLO performance clearly, some NLO dendrons and dendrimers with different chromophore moieties or different end-capped groups were carefully designed and investigated in detail. The results demonstrated that some strong Ar-Ar(F) interactions between the pentafluorop...

The multiple application of reductive amination on primary amino groups of first and second generation poly(propyleneimine) dendrimers is used as a one-pot approach to introduce twice the amount of the oligosaccharide units as surface groups, compared to initially present amino groups in the first and second generation dendrimers. This was proven by (1)H NMR, MALDI-TOF-MS, and LILBID-MS analysi...

Dendrimers have shown great promise as drug delivery vehicles in recent years because they can be synthesized with designed size and functionalities for optimal transportation, targeting, and biocompatibility. One of the most well-known termini used for biocompatibility is polyethylene glycol (PEG), whose performance is affected by its actual conformation. However, the conformation of individua...

The synthesis of multivalent dendritic cluster glycosides of mannopyranosyl-6-phosphate is presented. Poly(amido amine)-based dendrimers of 0.5-3.5 generations, containing carboxylic acid peripheral functionalities, were utilized so as to install 4, 8, 16 and 32 mannopyranosyl-6-phosphate residues at the peripheries of the dendrimers. Amide bond formation between an amine-tethered mannopyranosy...