Recognition and binding of anions in water is difficult due to the ability of water molecules to form strong hydrogen bonds and to solvate the anions. The complexation of two different carboxylates with 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied in aqueous solution using NMR and ITC binding models. Sodium 2-naphthoate and sodium 3-hydroxy-2-naphthoate were chosen as c...

This study describes the previously unreported intrinsic capacity of poly-L-lysine (PLL) sixth generation (G(6)) dendrimer molecules to exhibit systemic antiangiogenic activity that could lead to solid tumor growth arrest. The PLL-dendrimer-inhibited tubule formation of SVEC4-10 murine endothelial cells and neovascularization in the chick embryo chick chorioallantoic membrane (CAM) assay. Intra...

the neighbourhood polynomial g , is generating function for the number of faces of each cardinality in the neighbourhood complex of a graph. in other word $n(g,x)=sum_{uin n(g)} x^{|u|}$, where n(g) is neighbourhood complex of a graph, whose vertices are the vertices of the graph and faces are subsets of vertices that have a common neighbour. in this paper we compute this polynomial for some na...

The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide (LPS) to soluble MD-2. We have previously shown, in biologically based experiments, that a generation 3.5 PAMAM dendrimer with 64 peripheral carboxylic acid groups acts...

The analysis of the spatial structure of a rigid polyphenylene dendrimer G4-M of fourth generation by small-angle neutron scattering (SANS) is presented. This dendrimer is composed of phenyl units and is therefore devoid of any flexible unit. The scattering intensity of dilute solutions of the dendrimer was measured by SANS at different contrast which was adjusted by mixtures of protonated and ...

This study used refractometry, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and dielectric analysis to assess the viscoelastic properties and phase behavior of blends containing 0–20% (w/w) 12-tert-butyl ester dendrimer in poly(methyl methacrylate) (PMMA). Dendritic blends were miscible up through 12%, exhibiting an intermediate g...

In order to couple high cellular uptake and target specificity of dendrimer molecule with excellent optical properties of semiconductor nanoparticles, the interaction of cysteine-capped CdTe quantum dots with dendrimer was investigated through spectroscopic techniques. NH(2)-terminated dendrimer molecule quenched the photoluminescence of CdTe quantum dots. The binding constants and binding capa...

Platinum and palladium dendrimer-encapsulated nanoparticles (DENs) were prepared within commercially available, fourth-generation, amine-terminated, poly(amidoamine) dendrimers (G4-NH2). The synthesis is carried out by selectively encapsulating metal complexes within the dendrimer and then reducing the resulting composite. Intradendrimer complexation requires control over the solution pH to pre...

A new Cd10S16 molecular cluster dendrimer has been prepared and characterized; photooxygenation reaction using the molecular cluster dendrimer as a photosensitizer was successful.

Abstract Background In recent years, the use of ferritins as nano-vehicles for drug delivery is taking center stage. Compared to other similar nanocarriers, Archaeoglobus fulgidus ferritin particularly interesting due its unique ability assemble-disassemble under very mild conditions. Recently this was engineered get a chimeric protein targeted human CD71 receptor, typically overexpressed in ca...