Surgeons can now control osteogenesis through local application of BMP-2. BMP’s are osteoinductive proteins that are located in bone matrix and are responsible for embryonic skeletal formation and bone healing. Marshal Urist first coined the term “bone morphogenic protein” over 40 years ago. Recombinant human BMP-2 is an osteoinductive growth factor that has the potential to make autogenous bon...

Background Following injury to the rotator cuff and anterior cruciate ligament, a direct enthesis is not regenerated, and healing occurs with biomechanically inferior fibrous tissue. Demineralized bone matrix (DBM) is a collagen scaffold that contains growth factors and is a promising biological material for tendon and ligament repair because it can regenerate a direct fibrocartilaginous insert...

Introduction: Alveolar bone is the most affected of periodontal diseases. Bone grafts such as autograft, allograft, xenograft and, alloplastic often are used, but they have limitations. So, graft still a major problem that continues to inspire design new materials. The purpose this article review clinical and biologic function, advantages, disadvantages dentin an autograft allograft in therapy....

The mechanical properties of fully demineralized, fully deproteinized and untreated cortical bovine femur bone were investigated by compression testing in three anatomical directions (longitudinal, radial and transverse). The weighted sum of the stress-strain curves of the treated bones was far lower than that of the untreated bone, indicating a strong molecular and/or mechanical interaction be...

Two groups of cubic specimens from diaphysis of bovine femur, intact and completely demineralized, were axially compressed. One half of the samples from each group were loaded along the axis of the femur (L) and the other - perpendicularly (T). Intact samples were characterized in terms of elastic modulus; for demineralized samples secant modulus of elasticity was calculated. During compression...

Demineralized bone matrix (DBM) is one of the most widely used bone graft materials in dentistry. However, the ability of DBM to reliably and predictably induce bone regeneration has always been a cause for concern. The quality of DBM varies greatly depending on several donor dependent factors and also manufacturing techniques. In order to standardize the quality and to enable reliable and pred...

INTRODUCTION: Recent studies suggest that recombinant human bone morphogenic protein (rhBMP)-2 encased in a demineralized bone matrix scaffold (MS) is a comparable alternative to iliac crest bone grafting for secondary alveolar cleft repair. Post reconstruction occlusal radiographs are used to measure bone reconstitution but cannot evaluate bony growth in three dimensions. In this study, we use...

OBJECTIVES This study aimed to examine the influence of particle size and extent of demineralization of dentin matrix on bone regeneration. MATERIALS AND METHODS Extracted human teeth were pulverized and divided into 3 groups according to particle size; 200, 500, and 1000 μm. Each group was divided into 3 groups depending on the extent of demineralization; undemineralized dentin (UDD), partia...