نتایج جستجو برای: dehydro aromatization
تعداد نتایج: 1931 فیلتر نتایج به سال:
The high concentrations of estradiol i !•'. ,i found in breast tumors of postmenopausal women could be the result of enhanced uptake from plasma or in situ aromatization of androgens to estrogens. To test the relative importance of these two mechanisms, a model system allowing precise distinction between each is required. Such a model was established using aromatase (A + )and sham (A-)-transf...
The high concentrations of estradiol (E2) found in breast tumors of postmenopausal women could be the result of enhanced uptake from plasma or in situ aromatization of androgens to estrogens. To test the relative importance of these two mechanisms, a model system allowing precise distinction between each is required. Such a model was established using aromatase (A+)- and sham (A-)-transfected M...
Ascorbic acid is concentrated in various ocular compartments where it is thought to protect diurnal animal species against damaging effects of ultraviolet radiation. The authors evaluated the possibility that corneal endothelial cells have specific transport and/or metabolic properties that deliver ascorbic acid to the stroma. Bovine corneal endothelial cells were grown to confluence in multipl...
11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation.
In human plasma, 11-dehydrothromboxane (TX) B2 is a major long lived metabolite (t1/2 45 min) formed from infused TXB2, the hydration product of biologically active TXA2. Plasma concentrations of TXB2 itself are readily confounded by ex vivo platelet activation and, theoretically, an enzymatic derivative of this compound, not subject to formation in whole blood, would more accurately reflect TX...
High-resolution pulsed Fourier-transform nuclear magnetic resonance spectroscopy at 22.63 MHz was used to observe the proton-decoupled natural-abundance (13)C nuclear magnetic resonance spectra of CDCl(3) solutions of the methyl esters of prostaglandins F(1alpha), 15-epi-F(1alpha), F(2alpha), F(2beta), E(2), A(2), 13-dehydro-F(2alpha), 13-dehydro-F(3alpha), two intermediates on the synthetic pa...
A variety of heteroaromatic compounds, such as substituted pyridines, pyrazoles, indoles, 2-substituted imidazoles, 2-substituted imidazoles, 2-arylbenzazoles and pyrimidin-2(1H)-ones are synthesized by oxidative aromatization using the activated carbon and molecular oxygen system. Mechanistic study focused on the role of activated carbon in the synthesis of 2-arylbenzazoles is also discussed. ...
This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the infl...
Thirteen postmenopausal women with advanced breast cancer were enrolled in an open randomized Phase I trial of a new p.o. active aromatase inhibitor, CGS 20267 (letrozole). The primary aim of the trial was to assess the impact of two doses of letrozole (0.5 and 2. 5 mg/day) on the peripheral aromatization of androstenedione to estrone. An in vivo isotopic technique was used to measure periphera...
This paper addresses the techno-economic analysis of the propane aromatization process, by adopting a novel kinetics-to-process approach. The recent interest in this technological route derives from the development of new third generation biorefinery concepts, in which, algal oil is subjected to catalytic hydrodeoxygenation processes for the production of (Hydrotreated Renewable Jet) HRJ fuels....
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