Inhibition of the proteasome (a highly abundant enzymatic complex responsible for intracellular protein turnover) is an effective anti-cancer therapeutic approach, as demonstrated by the first-in-class agent bortezomib. Various new proteasome inhibitors are now in development, including peptide boronic acid analogs MLN9708 and CEP-18770, peptide epoxyketones carfilzomib and PR-047, and NPI-0052...

the principal effects of mass degradation on polymer matrix composites (pmcs) are the decay of mechanical properties such as strength, elongation, and resilience. this degradation is a common problem of the pmcs under thermal cycling conditions. in this article, composite degradation was investigated by measurement of total mass loss (tml) using the taguchi approach. thermal cycling tests were ...

India has large resources of natural fibres such as Banana, Khus, Sisal, Korai grass,Talipot, Palm leaf, Coconut, Pineapple, Screwpine, Golden grass, Jute and Sabaiamong others. In the past, trade of the village folk depended on harvesting fibresgrown in their villages. Natural fibers have recently gaining attraction of researchersdue to their low cost eco-friendly and biodegradability characte...

soil degradation means lose of soil quality which usually is caused by improper use of land by human. decline of soil quality includes lose of physical, chemical and biological properties of soil. this study aimed to identify and assess the quality of soil and land, to determine the type of land degradation and estimates their severity based on completed forms gathered field data and mapping th...

Degradation of mRNA contributes to variation in transcript abundance. Studies of individual mRNAs have shown that both cis and trans factors affect mRNA degradation rates. However, the factors underlying transcriptome-wide variation in mRNA degradation rates are poorly understood. We investigated the contribution of different transcript properties to transcriptome-wide degradation rate variatio...

The development of living heart valves that grow with the patient is a promising strategy for heart valve replacements in pediatric patients. Despite active research in the field of tissue engineered heart valves there have been limited efforts to optimize the balance between biodegradation of the scaffolds and de novo extracellular matrix (ECM) synthesis by cells and study their consequences o...