Accurate estimates of future age-specific incidence andmortality are critical for allocation of resources to breast cancer control programs and evaluation of screening programs. The purpose of this study is to apply functional data analysis techniques tomodel age-specific breast cancer mortality time trends, and forecast entire age-specific mortality functions using a state-space approach. We u...

Accurate estimates of future age-specific incidence and mortality are critical for allocation of resources to breast cancer control programmes and evaluation of screening programmes. The purpose of this study is to apply functional data analysis techniques to model age-specific breast cancer mortality time trends, and forecast entire age-specific mortality functions using a state-space approach...

It has been suggested that the rate of CD4 cell decline accelerates in parallel with decreasing numbers of cells; however, the statistical literature suggests the opposite. CD4 cells were counted about every 6 months in a cohort of 1264 human immunodeficiency virus-infected subjects (the Italian Seroconversion Study cohort). Kaplan-Meier analysis was used to estimate the time for CD4 cells to d...

INTRODUCTION Both theoretical and statistically derived approaches have been used in research settings for predicting cognitive decline. METHODS Fifty-eight cognitively normal (NC) and 71 mild cognitive impairment (MCI) subjects completed a comprehensive cognitive battery for up to 5 years of follow-up. Composite indices of cognitive function were derived using a classic theoretical approach ...

It is difficult to distinguish the onset of renal function decline from the typical variation in estimated glomerular filtration rate (eGFR) measurements in clinical practice. In this study, we used data analysis incorporating smoothing techniques to identify significant trends despite large amounts of noise. We identified the starting points of meaningful eGFR decline based on eGFR trajectorie...

Shale gas reservoirs have huge amounts of reserves. Economically evaluating these reserves is challenging due to complex driving mechanisms, drilling and completion configurations, the complexity controlling producing conditions. Decline Curve Analysis (DCA) historically considered easiest method for production prediction unconventional as it only requires history. Besides uncertainties in sele...

compound action potential (cap) of spinal cord represents valuable properties of neural fibers including excitability, rate of myelination and membrane integrity. these properties are measured using amplitude, latency and area under curve of caps recorded from spinal cord. here, the isolated spinal cord was set in a double sucrose gap (dsg) chamber and its response to intracellular stimulation ...