Background One of the most important unit operations in upstream animal cell bioprocesses at scales over 100 L is the preparation and sterilization of the medium. This complex, sensitive, and expensive process requires a considerable investment in both material and time [1]. Traditionally, large-scale medium sterilization is performed with costly single-use dead-end filters. To optimize and red...

Soft neighborhood substitutability (SNS) is a powerful technique to automatically detect and prune dominated solutions in combinatorial optimization. Recently, it has been shown in [26] that enforcing partial SNS (PSNS) during search can be worthwhile in the context of Weighted Constraint Satisfaction Problems (WCSP). However, for some problems, especially with large domains, PSNS is still too ...

A theoretical and experimental study of the acoustic properties of porous materials containing dead-end (or partially opened) porosity was recently proposed by Dupont, Leclaire, Sicot, Gong, and Panneton [J. Appl. Phys. 110, 094903 (2011)]. The present article provides a description of partially opened porosity systems and their numerous potential applications in the general context of the stud...

Revealing Adverse Drug Reactions (ADR) is an essential part of post-marketing drug surveillance, and data from health-related forums and medical communities can be of a great significance for estimating such effects. In this paper, we propose an end-to-end CNNbased method for predicting drug safety on user comments from healthcare discussion forums. We present an architecture that is based on a...

Full genome sequences of 20 strains of Clostridium chauvoei, the etiological agent of blackleg of cattle and sheep, isolated from four different continents over a period of 64 years (1951-2015) were determined and analyzed. The study reveals that the genome of the species C. chauvoei is highly homogeneous compared to the closely related species C. perfringens, a widespread pathogen that affects...