I. Overview Dynamic Contrast Enhanced MRI (DCE-MRI) is a rapidly evolving imaging technique, and it is widely applicable in management of various cancers. It is the current standard for breast MR imaging; also many research studies have been conducted to evaluate its application for other cancers. This tutorial is focused on the analysis of DCE-MRI data, and how the analyzed parameters are used...

Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management....

Recent progress in imaging technologies leads to a continuous growth in biomedical data, which can provide better insight into important clinical and biological questions. Advanced machine learning techniques, such as artificial neural networks are brought to bear on addressing fundamental medical image computing challenges such as segmentation, classification and reconstruction, required for m...

Dynamic contrast-enhanced resonance imaging (DCE-MRI) plays an important role in oncology. During a number of scans, a contrast agent, usually a Gadolinium complex like gadopentate (Gd-DTPA) is injected into the patient. DCE-MRI scans show the flow of the contrast agent, and therefore the blood flow, between vascular space and extracellular extravascular space (EES), since the contrast agent is...

Purpose: The growing importance of dynamic contrast-enhanced MRI (DCE-MRI) in the oncological application prompted us to examine its clinical feasibility in patients with suboptimal scanning condition, in our case: the patients of malignant oral cavity tumors susceptible to motion artifact and image distortion due to coughing, swallowing, fixed dental implant and etc. We aimed to examine (1) ho...

OBJECTIVE Dynamic contrast-enhanced (DCE-MRI) time-intensity curve (TIC) shape analysis has previously been used in oncology, where fast initial enhancement and early washout are associated with malignancy. As RA synovium has some tumour-like features, we investigated DCE-MRI TIC shape expression in early arthritis in relationship to diagnosis. METHODS Twenty-eight DMARD-naïve, early arthriti...

The aim of the study was to investigate dynamic contrast enhanced MRI (DCE-MRI) as a potential marker to assess the therapeutic responses of fecal microbiota transplantation (FMT) in patients with Crohn's disease (CD) and to determine the parameter or combination of parameters most strongly associated with changes in clinical indicators after treatment.In 22 CD patients, DCE-MRI was performed w...

In Dynamic Contrast Enhanced Resonance Imaging (DCE-MRI), abdomen is scanned repeatedly and rapidly after injection of a contrast agent. During data acquisition, collected images suffer from the motion induced by the patient if he/she moves or breathes heavily during the scan. Therefore, these images should be aligned accurately to correct the motion. Recently, mutual information (MI) registrat...

PURPOSE To clinically evaluate a highly accelerated T1-weighted dynamic contrast-enhanced (DCE) MRI technique that provides high spatial resolution and whole-brain coverage via undersampling and constrained reconstruction with multiple sparsity constraints. METHODS Conventional (rate-2 SENSE) and experimental DCE-MRI (rate-30) scans were performed 20 minutes apart in 15 brain tumor patients. ...

Purpose To develop a robust and clinically applicable automated method for analyzing Dynamic Contrast Enhanced (DCE-) MRI of the prostate as a guide for targeted biopsies and treatments. Materials and methods An unsupervised pattern recognition (PR) method was used to analyze prostate DCE-MRI from 71 sequential radiotherapy patients. Identified regions of interest (ROIs) with increased perfus...