In contrast to other replication systems, adenovirus DNA replication does not require a DNA helicase to unwind the double-stranded template. Elongation is dependent on the adenovirus DNA-binding protein (DBP) which has helix-destabilizing properties. DBP binds cooperatively to single-stranded DNA (ssDNA) in a non-sequence-specific manner. The crystal structure of DBP shows that the protein has ...

MOTIVATION To detect and select patterns of transcription factor binding sites (TFBSs) which distinguish genes directly regulated by estrogen receptor-alpha (ERalpha), we developed an innovative mixture model-based discriminate analysis for identifying ordered TFBS pairs. RESULTS Biologically, our proposed new algorithm clearly suggests that TFBSs are not randomly distributed within ERalpha t...

Microorganisms capable of degrading di-n-butyl phthalate (DBP) were immobilized by polyvinyl alcohol (PVA) and used for DBP degradation. The characteristics of DBP degradation by immobilized and free cells were investigated. The experimental results showed that the degradation rate o f immobilized cells was higher than that of free cells. The optimal pH and temperature for DBP degradation were ...

Water pollution by wastewater discharge can cause the problem of disinfection byproducts (DBPs) in drinking water supply. In this study, DBP formation characteristics of soluble microbial products (SMPs) as the main products of wastewater organic biodegradation were investigated. The results show that SMPs can act as DBP precursors in simulated wastewater biodegradation process. Under the exper...

Vitamin D-binding protein (DBP) has been reported to contribute to innate immunity. To verify prior in vitro and cell-based observations supporting this role, we assessed the ability of a recently developed DBP-null mouse line to recruit neutrophils and macrophages to a site of chemical inflammation. The interrupted DBP allele had been generated by homologous recombination in 129X1/SvJ embryoni...

Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...

Dibutyl phthalate (DBP) is used widely as a plasticizer and is thought to negatively affect various organisms. To isolate and investigate DBP-degrading bacteria from hydrospheres in Tokyo, strains were selected on YNB medium containing DBP as the sole carbon source, and candidate strains were identified by zones of clearing around the colonies. Degradation of DBP by the strains was subsequently...

Plasma-derived vitamin D binding protein (DBP) is an important physiologic regulator of the neutrophil chemotactic response to activated complement. A cell-associated form of DBP has been observed in numerous cell types. We now report that mature, circulating human neutrophils also contain cell-associated DBP. Immunofluorescence studies of normal untreated neutrophils showed the presence of DBP...

Age (years, mean±SD) DM (%) Current smoker (%) Blood pressure (mmHg, %) Optimal (SBP<120, DBP<80) Normal (SBP<130, DBP<85) High normal (SBP<140, DBP<90) Stage I HT (SBP<160, DBP<100) Stage II to IV HT (SBP>=160, DBP ≥ 100) Total cholesterol (mg/dl, %) <160 160-199 200-239 240-279 ≥ 280 LDL cholesterol (mg/dl, %) >130 130-159 >160 HDL cholesterol (mg/dl, %) <35 35-44 45-49 50-59 ≥ 60 Creatinine ...