The human Melan-A/MART-1 gene encodes an HLA-A2-restricted peptide epitope recognized by melanoma-reactive CD8(+) cytotoxic T lymphocytes. Here we report that this gene also encodes at least one HLA-DR4-presented peptide recognized by CD4(+) T cells. The Melan-A/MART-1(51-73) peptide was able to induce the in vitro expansion of specific CD4(+) T cells derived from normal DR4(+) donors or from D...

A fuzzy neural network, Falcon-MART, is proposed in this paper. This is a modi®cation of the original Falcon-ART architecture. Both Falcon-ART and Falcon-MART are fuzzy neural networks that can be used as fuzzy controllers or applied to areas such as forgery detection, pattern recognition and data analysis. They constitute a group of hybrid systems that incorporate fuzzy logic into neural netwo...

Suboptimal activation of T lymphocytes by tumor cells may contribute to the failure of the immune system to control tumor growth. We recently demonstrated that Melan-A/MART-1-reactive CTLs can be anergized by peptide analogues with partial agonist/antagonist functions, which selectively impair interleukin (IL)-2 release. Here we analyze the potential expression of partial agonist/antagonist pep...

The discovery of human melanoma rejection Ags has allowed the rational design of immunotherapeutic strategies. One such Ag, MART-1, is expressed on >90% of human melanomas, and CTL generated against MART-1(27-35) kill most HLA A2.1(+) melanoma cells. However, variant tumor cells, which do not express MART-1, down-regulate MHC, or become resistant to apoptosis, will escape killing. Cytotoxic lym...

Recent nrDNA and trnC-trnD sequence data revealed that J. monticola and J. m. f. compacta are not monophyletic, and this prompted additional research using Single Nucleotide Polymorphisms (SNPs). The SNPs data clearly show that J. monticola f. compacta is not conspecific with J. monticola f. monticola. Juniperus monticola f. compacta Mart. is raised to the specific level as: Juniperus compacta ...

1Department of Physical Medicine and Rehabilitation, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey 2Department of Internal Medicine, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey 3Department of Clinical Biochemistry, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey 4Department of Microbiology, Medical Faculty of Çanakkal...

This paper is interested in the graphical manipulation of data mart schemes described in XML and issued from a generation module of multidimensional models. This manipulation is performed through a set of operations we have defined. These operations consist in adding, deleting and renaming the multidimensional

The environments where medical records are explored for historical analysis of clinical scenes, in general, have focus on integration of data that are, essentially, structured. However, they face difficulties to handle other types of information present, e.g. on anamnesis, due to their unstructured nature. This paper presents an environment for multifaceted analysis of me...

This paper introduces Sharing-Mart (S-Mart), an online digital trading platform developed at Princeton University to perform social file sharing experiments on top of technological networks as overlays. It describes the S-Mart system, the experiments conducted, and incentivization aspects which can be investigated using S-Mart. In the first part of the paper, the S-Mart system and the experimen...

This paper introduces Sharing-Mart (S-Mart), an online digital trading platform developed at Princeton University to perform social file sharing experiments on top of technological networks as overlays. It describes the S-Mart system, the experiments conducted, and incentivization aspects which can be investigated using S-Mart. In the first part of the paper, the S-Mart system and the experimen...