نتایج جستجو برای: darius i 522
تعداد نتایج: 1041050 فیلتر نتایج به سال:
MicroRNAs (miRNAs) are small non-coding RNAs, which are important in the development of multidrug resistance in cancer by regulating gene expression at the post‑transcriptional level. The present study investigated the functional effects of miR‑522 in chemoresistant colon cancer cells. The results demonstrated that miR‑522 was significantly downregulated in doxorubicin (DOX) resistant colon cel...
Selective cyclooxygenase-2 (COX-2) inhibitors have been demonstrated to inhibit the proliferation of a variety of cancer cells including hepatocellular carcinoma (HCC). We sought to explore the mechanisms by which JTE-522, a selective COX-2 inhibitor, suppressed the growth of human HCC cells. HCC cells (HepG2, HLF, huH1, Huh7, and PLC/PRF/5 cells) did not express COX-2 at either the mRNA or pro...
The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity while avoiding these central nervous system side effects. In the current study, a novel compound (TX...
Darius offered the political order of “king of kings” to solve the political crisis of his era. He legitimized it based on an order of gods. In his belief, the nature of politics was based on a dualistic religious worldview that is the fight between true divinity and false divinity’s will and performance in the world. In addition, the chief true divinity’s law was introduced as the principle or...
CONTENTS 36.1 Bio-Char Management and Soil Nutrient Availability ............................................. 518 36.2 Microbial Cycling of Nutrients in Soils with Bio-Char ............................................ 519 36.3 Biological Nitrogen Fixation in Soils with Bio-Char................................................. 521 36.4 Slash-and-Char as an Alternative to Slash-and-Burn ...........
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