Previous work has demonstrated that in utero cocaine exposure induces an uncoupling of brain D(1A) dopamine receptors (D(1A)DARs) from G(s)-protein. The present work is an attempt to define the mechanism underlying the uncoupling. We detected a significant elevation of phosphoserine in frontal cortical D(1A)DARs of rabbits that were exposed prenatally to cocaine compared with saline controls. T...

INTRODUCTION Dopamine (DA) binds to five receptors (DAR), classified by their ability to increase (D1R-like) or decrease (D2R-like) cAMP. In humans, most DA circulates as dopamine sulfate (DA-S), which can be de-conjugated to bioactive DA by arylsulfatase A (ARSA). The objective was to examine expression of DAR and ARSA in human adipose tissue and determine whether DA regulates prolactin (PRL) ...

ADC bioanalytical strategies With the US FDA approval of Adcetris® (brentuximab vedotin) in 2011 and Kadcyla® (ado-transtuzumab emtansine) in 2013, antibody-drug conjugate (ADC) has been a hot topic in industry. Because of the complexity of an ADC, combining monoclonal antibody and small molecule toxin, its bioanalysis has seen unprecedented amount of discussion compared to other drug modalitie...

Bürokratie stellt eine Belastung für Unternehmen dar. Auf Grund der kleinbetrieblichen Strukturen in der deutschen Landwirtschaft sind davon landwirtschaftliche Betriebe besonders stark betroffen. Der folgende Beitrag stellt Methoden dar, mit denen in der Vergangenheit die Belastung von landwirtschaftlichen Betrieben durch Bürokratie erhoben wurde. Die Belastungen werden einander gegenüber gest...

1 Environment Department, York Institute for Tropical Ecosystems, University of York, York, United Kingdom, 2 Department of Archaeology and Ancient History, Uppsala University, Uppsala, Sweden, 3 Department of History, University of Dar es Salaam, Dar es Salaam, Tanzania, 4 Department of Archaeology, University of York, York, United Kingdom, 5 School of Geography, Archaeology and Environmental ...

148 Correspondence (‹letiflim): Gh Nabi Dar, M.D. Department of Orthopaedics, Gove r n m e n t Medical College Srinagar, Kashmir, India. Tel: +09 1 0 1 9 4 2424660 Fax ( F a k s ): +09 1 0 1 9 4 243730 e-m a i l ( e -p o s t a) : d r g n d a r @ y a h o o . c o . i n Department of Orthopaedics, Government Medical College Srinagar, University of Kashmir, Kashmir, India. Kaflmir Üniversitesi, Sri...

'~nstitute of Traditional Medicine, Muhumbili Universiy College of Health Sciences, P.O. Box 38009, Dar es salaam, Tanzania. 2 Department of Pharmacognosy, School of Pharmacy, Muhimbili University College of Health Sciences, Box 65001, Dar es Salaam, Tanzania. 3~aboratmium voor Farmaceutische Biologie en Fytofarrnacologie, Faculteit Farmaceutische, Wetenschappen, Katholieke Uciversiteit Leuven,...

The analysis of DAR IMPATT diodes has been realized on basis of the precise drift-diffusion nonlinear model. The admittance characteristics of the DAR diode were analyzed in very wide frequency band from 30 up to 360 GHz. The energy characteristics have been optimized for the second high frequency band near the 220 GHz.

Document Analysis and Recognition (DAR) aims at the automatic extraction of information presented on paper and initially addressed to human comprehension. The desired output of DAR systems is usually in a suitable symbolic representation that can subsequently be processed by computers. Over the centuries, paper documents have been the principal instrument to make permanent the progress of the h...

Re: Resubmission of the Revised Paper Titled " Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania " for Publication I, Said Aboud, the author of the paper titled " Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania " have incorporated the following formatting c...