Sp1, a transcription factor that regulates expression of a wide array of essential genes, contains two SQ/TQ cluster domains, which are characteristic of ATM kinase substrates. ATM substrates are transducers and effectors of the DNA damage response, which involves sensing damage, checkpoint activation, DNA repair, and/or apoptosis. A role for Sp1 in the DNA damage response is supported by our f...

Radiotherapy is successfully used to treat neoplastic lesions, but may adversely affect normal tissues within the irradiated volume. However, additional clinical and para-clinical data are required for a comprehensive understanding of the pathogenesis of this damage. We assessed a rat model using clinical records and medical imaging to gain a better understanding of irradiation-induced tissue d...

Rock block tilting is one of the most common types dangerous rock failures with no clear indicator displacement prior to failure. Existing stability evaluation methods remain limited in their ability constrain non-penetrating section area, which closely related stability, and evaluations are therefore associated large uncertainties. The dynamic characteristic parameters toppling structural plan...

Transmission and analytical electron microscopy have been used to characterize the numerous lenticular fissures which were observed in electron micrographs of paragonite. Observations with a very weak electron beam revealed that there were no fissures in the original paragonite and that the degree of damage is a function of exposure to the beam. AEM analysis revealed that there is significant l...

Tactile thresholds were measured in six patients with psychogenic hypaesthesia using a forced choice procedure. The response to stimuli close to threshold differed in a characteristic manner from that seen in patients with peripheral or central nervous system damage.

We describe a patient with a suprarenal pheochromocytoma that had a complex course with electrocardiographic findings characteristic of diffuse myocardial damage, normal findings on coronary angiography, and left intraventricular thrombus complicated by embolic stroke.

Viruses can interact with host cell molecules responsible for the recognition and repair of DNA lesions, resulting in dysfunctional DNA damage response (DDR). Cells with inefficient DDR are more vulnerable to therapeutic approaches that target DDR, thereby raising DNA damage to a threshold that triggers apoptosis. Here, we demonstrate that 2 Jurkat-derived cell lines with incorporated silent HI...

We investigate the effect on the roughness of microcrack nucleation ahead of a propagating planar crack and study the structure of the damage zone. To this end we consider a quasi-two dimensional random fuse model, confining the crack between two horizontal plates. The two-dimensional geometry introduces a characteristic length in the problem, limiting the crack roughness. The damage ahead of t...

Acute exposure to ultraviolet light to 257 nm wavelength produced a photokeratitis associated with characteristic metabolic alterations of corneal epithelial metabolism in rabbits. Significant increases in corneal hydration occurred simultaneously with decreased corneal epithelial glycogen content, but adenosine triphosphate content and enzyme activity of epithelial extracts were not affected d...