background: the role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. this study was performed to evaluate the possible protective effect of vitamins e and c, against endosulfan-induced reproductive toxicity in rats. methods: fifty adult male sprague–dawley rats were randomly divided into five groups (n=10 each). the groups included a control receiving vehicl...

Sertoli cell proliferation is attenuated before attaining puberty and the number is fixed in adult testes. Sertoli cells determine both testis size and daily sperm production by providing physical and metabolic support to spermatogenic cells. Polychlorinated biphenyls (PCBs) exposure disrupts functions of Sertoli cells causing infertility with decreased sperm count. On the other hand, lycopene ...

UNLABELLED Objectives : The aim of the present study was to evaluate protective effect of royal jelly on sperm parameters, testosterone level, and malondialdehyde (MDA) production in mice. MATERIALS AND METHODS Thirty-two adult male NMRI mice weighing 30±2 g were used. All the animals were divided into 4 groups. CONTROL GROUP received saline 0.1 ml/mouse/day orally for 30 days. Royal jelly ...

quantitative histology of the descended testis of unilateral cryptorchid bucks was compared with testis of normal bucks to evaluate the reproductive potentials of the scrotal testis in unilateral cryptorchids, using light microscopy techniques. the contralateral scrotal testes of the unilateral cryptorchids and the testes of the normal bucks contained profiles of seminiferous epithelium and eac...

Lead is the known environmental contaminant adversely affecting the male reproductive system in human and experimental animals. The cytotoxic effects of lead on male reproductive system involve the production of reactive oxygen species (ROS) and oxidative damage in tissue. The higher quantities of ROS in testicular tissue detrimentally affected developing germ cells so as to produce verities of...

Background Oxidative stress has been suggested to be a major cause of reproductive failure. Arsenic as an environmental toxicant can exert malformation in the reproductive system by inducing oxidative stress. Ascorbic acid, a potent antioxidant, is able to restrict oxidative stress. The aim of this study was to investigate the adverse effect of sodium arsenite on the germ cells population and d...

A single in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on gestation day 15 decreased epididymal sperm count in adult rats and thus was used to establish a tolerable daily intake for TCDD. However, several laboratories have been unable to replicate these findings. Moreover, conflicting reports of TCDD effects on daily sperm production suggest that spermatogenesis may not be as ...