There are three evolving facets to design: 1) the artifact to be designed, 2) the design process, and 3) the tools available to aid the design process. They are evolving because first, the design process is becoming more complex due to the need to consider the entire product life-cycle—from conception to manufacturing to sales to maintenance. Second, the artifacts of design are changing in that...

Treatments with nonsteroidal anti-inflammatory drugs (NSAIDs) have increased the number of patients with gastrointestinal complications. Qing Dai has been traditionally used in Chinese herbal medicine for various inflammatory diseases such as ulcerative colitis. We previously reported that Qing Dai suppressed inflammations by scavenging reactive oxygen species (ROS) in ulcerative colitis patien...

Impairments in cognition, pain intolerance, and physical inactivity characterize adolescent chronic fatigue syndrome (CFS), yet little is known about its neurobiology. The right dorsal anterior insular (dAI) connectivity of the salience network provides a motivational context to stimuli. In this study, we examined regional functional connectivity (FC) patterns of the right dAI in adolescent CFS...

PRIMARY OBJECTIVE Errorless learning has been reported to be effective in the rehabilitation of patients with impaired cognitive functions following brain injury. This study compared brain activations in errorless learning (EL) and errorful learning (EF) in patients with diffuse axonal injury (DAI) using a functional magnetic resonance imaging (fMRI). METHODS AND PROCEDURES The participants w...

Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA-dependent activator of IRFs/Z-DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nuclear factor-kappa B (NF-kappaB) transcription factors, leading to type-I interferon production. DAI-induced IRF activation depends on TANK-bin...

In this paper we demonstrate how to monitor a smartphone running Symbian operating system and Windows Mobile in order to extract features for anomaly detection. These features are sent to a remote server because running a complex intrusion detection system (IDS) on this kind of mobile device still is not feasible due to capability and hardware limitations. We give examples on how to compute rel...

Diffuse axonal injury (DAI) is the most common and significant pathological features of traumatic brain injury (TBI). However, there are still no effective drugs to combat the formation and progression of DAI in affected individuals. FK506, also known as tacrolimus, is an immunosuppressive drug, which is widely used in transplantation medicine for the reduction of allograft rejection. Previous ...

The current work reviews the concept, pathological mechanism, and process of diagnosing of DAI. The pathological mechanism underlying DAI is complicated, including axonal breakage caused by axonal retraction balls, discontinued protein transport along the axonal axis, calcium influx, and calpain-mediated hydrolysis of structural protein, degradation of axonal cytoskeleton network, the changes o...

OGSA-DAI provides an extensible Web service-based framework that allows data resources to be incorporated into Grid fabrics. The current OGSA-DAI release (OGSADAI WSI/WSRF v2.2) has implemented a set of optimizations identified through the examination of common OGSA-DAI use patterns. In this paper we describe these patterns and detail the optimizations that have been made for the current releas...

objective: non-compliance is one of the major problems in treatment of patients with schizophrenia. it is also the most significant risk factor for relapse and re-hospitalization. previous studies showed that 25-70% of all patients with schizophrenia have negative attitudes to drugs. therefore, the present study aimed to identify the relationship between drug attitude and discharge and the rate...