AIMS Detrusor after-contractions (DAC) are non-common in adults. Both definition (nothing in ICS reports) and significance (artefact, link with detrusor overactivity (DO) or bladder outlet obstruction (BOO)) remain discussed. Our purpose was to carry out an analysis of the urodynamic parameters during voidings with DAC and, using the VBN model, to simulate pathophysiological conditions able to ...

h THE 50TH DESIGN Automation Conference (DAC) was held in June of 2013. Fifty years of anything is amazing, especially in our young industry. To celebrate, DAC asked attendees to contribute their DAC moments. Here are a few excerpts, edited for space. You can find the complete set of DACMoments at http://dac.com/content/my-dac-moment-50-yearsmemories. Thenext DAC, the 51st, will be held in San ...

The epigenetic silencing of tumor suppressor genes in myelodysplastic syndromes (MDS) can potentially confer a growth advantage to individual cellular clones. Currently, the recommended treatment for patients with high-risk MDS is the methylation agent decitabine (DAC), a drug that can induce the reexpression of silenced tumor suppressor genes. We investigated the effects of DAC treatment on th...

Distributed Arithmetic Coding (DAC) is an effective implementation of Slepian-Wolf coding, especially for short data blocks. To research its properties, the concept of DAC codeword distribution along proper and wrong decoding paths has been introduced. For DAC codeword distribution of equiprobable binary sources along proper decoding paths, the problem was formatted as solving a system of funct...

This paper presents a self-test self-correction scheme for segmented current steering (CS) DACs. Prior art is critically analyzed. The new scheme improves the DAC linearity by improving the accuracy of the thermometer current sources. The algorithm, which controls the scheme, is described in details. A 12-bit CS DAC, with 6-6 segmentation, is implemented using the new scheme and algorithm. The ...

In this article, an on-chip self-calibrated 8bit R-2R digital-to-analog converter (DAC) based on digitally compensated input offset of the operational amplifier (OPAMP) is presented. To improve the overall DAC performance, a digital offset cancellation method was used to compensate deviations in the input offset voltage of the OPAMP caused by process variations. The whole DAC as well as offset ...

A digital to analogue converter (DAC) based on a single-electron tunnelling transistor (SETT) is proposed. The proposed scheme fully utilises the Coulomb blockade effect and only a SETT and n+1 capacitors are necessary for an n-bit DAC implementation. Using this scheme, a 4-bit DAC is demonstrated by means of simulation.

OBJECTIVE To assess the relationship between CD56(bright) natural killer (NK) cells and multiple sclerosis (MS) disease activity in patients with relapsing-remitting MS treated with daclizumab high-yield process (DAC HYP). METHODS Data were from patients enrolled in a 52-week randomized, double-blind, placebo-controlled study of DAC HYP and its extension study. Assessments included relationsh...

PURPOSE The DNA methylation inhibitor 5-aza-2'-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes (MDS), but resistance to DAC develops during treatment and mechanisms of resistance remain unknown. Therefore, we investigated mechanisms of primary and secondary resistance to DAC in MDS. PATIENTS AND METHODS We performed Quantitative Real-Time PCR to examine expressi...

PURPOSE To analyse the role of von Hippel-Lindau (VHL) and transforming growth factor β-induced (TGFBI) in synergistic mechanisms of 5-aza-2'-deoxycytidine (DAC) and paclitaxel (PTX) against renal cell carcinoma (RCC). METHODS To elucidate the role in the synergy between DAC and PTX against RCC cells, TGFBI expression was regulated using siRNA technology and an expression vector containing th...