نتایج جستجو برای: d10 value

تعداد نتایج: 734791  

ابراهیمی, مرضیه, رجبی فومشی, مطهره, رودی, راحله, صمدی کوچکسرایی, علی, مجد, زهرا, نصرالله زاده ثابت, مهرداد,

Background: The cancer stem cells (CSCs) are involved in invasion and metastasis of melanoma, the most lethal and aggressive form of skin cancer. In the present study, the expression of putative stem cell markers CD133 and ALDH1 were evaluated in melanoma cell lines and then the cells sorted based on the expression of these markers. Methods: In the present study expression of CD133 and A...

Journal: :Organic & biomolecular chemistry 2018
Alexandre Barrozo Qinghua Liao Mauricio Esguerra Gaël Marloie Jan Florián Nicholas H Williams Shina Caroline Lynn Kamerlin

β-Phosphoglucomutase (β-PGM) has served as an important model system for understanding biological phosphoryl transfer. This enzyme catalyzes the isomerization of β-glucose-1-phosphate to β-glucose-6-phosphate in a two-step process proceeding via a bisphosphate intermediate. The conventionally accepted mechanism is that both steps are concerted processes involving acid-base catalysis from a near...

Journal: :The New phytologist 2006
Lihong Zhang Patrick F Byrne Elizabeth A H Pilon-Smits

Selenium is essential for many organisms, but is toxic at higher levels. To investigate the genetic basis of selenate tolerance in Arabidopsis thaliana, quantitative trait loci (QTL) associated with selenate tolerance in accessions Landsberg erecta and Columbia were mapped using recombinant inbred lines (RILs). The selenate tolerance index (TI(D10) = root growth + 30 microm selenate/root growth...

Journal: :Oman medical journal 2015
Anjan Das Susanta Halder Surajit Chattopadhyay Parthajit Mandal Subinay Chhaule Rezina Banu

OBJECTIVES Improvements in perioperative pain management for lower abdominal operations has been shown to reduce morbidity, induce early ambulation, and improve patients' long-term outcomes. Dexmedetomidine, a selective alpha-2 agonist, has recently been used intrathecally as adjuvant to spinal anesthesia to prolong its efficacy. We compared two different doses of dexmedetomidine added to hyper...

Journal: :The Biochemical journal 2009
Marie F Soulière Jean-Pierre Perreault Martin Bisaillon

Decapping enzymes are required for the removal of the 5'-end cap of mRNAs. These enzymes exhibit a specific hydrolase activity, resulting in cleavage between the alpha- and beta-phosphates of the m7GpppN cap to generate both m7GDP and monophosphorylated RNA products. Decapping enzymes have been found in humans, plants and yeasts, and have been discovered more recently in vaccinia virus (D10 pro...

2016
Thomas Krüwel Damien Nevoltris Julia Bode Christian Dullin Daniel Baty Patrick Chames Frauke Alves

The detection of tumours in an early phase of tumour development in combination with the knowledge of expression of tumour markers such as epidermal growth factor receptor (EGFR) is an important prerequisite for clinical decisions. In this study we applied the anti-EGFR nanobody (99m)Tc-D10 for visualizing small tumour lesions with volumes below 100 mm(3) by targeting EGFR in orthotopic human m...

Journal: :Journal of immunology 2003
Ru-Ran Mo Julie K Eisenbraun Joanne Sonstein Ronald A Craig Jeffrey L Curtis Lloyd M Stoolman Jun Chen Raymond L Yung

D10.G4.1 (D10) cells, a murine conalbumin-reactive Th2 cell line, made to overexpress the beta(2) integrin LFA-1 by pharmacological manipulation or by transfection become autoreactive and are capable of inducing in vivo autoimmunity. However, whether this is specific to LFA-1 and whether overexpression of other T cell integrin molecules has the same effect are unknown. We examined the functiona...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Rossana Galassi Mukunda M Ghimire Brooke M Otten Simone Ricci Roy N McDougald Ruaa M Almotawa Dieaa Alhmoud Joshua F Ivy Abdel-Monem M Rawashdeh Vladimir N Nesterov Eric W Reinheimer Lee M Daniels Alfredo Burini Mohammad A Omary

Outer-shell s0/p0 orbital mixing with d10 orbitals and symmetry reduction upon cupriphication of cyclic trinuclear trigonal-planar gold(I) complexes are found to sensitize ground-state Cu(I)-Au(I) covalent bonds and near-unity phosphorescence quantum yields. Heterobimetallic Au4Cu2 {[Au4(μ-C2,N3-EtIm)4Cu2(µ-3,5-(CF3)2Pz)2], (4a)}, Au2Cu {[Au2(μ-C2,N3-BzIm)2Cu(µ-3,5-(CF3)2Pz)], (1) and [Au2(μ-C2...

Journal: :Cancer research 1986
N Sato T Sato S Takahashi K Kikuchi

We have reported previously that 100% of the incidence of malignant endotheliomas and angiosarcomas was developed in specific-pathogen-free BALB/c mice given s.c. injections of 1,2-dimethylhydrazine dihydrochloride. These tumors appeared selectively in the liver. In the present study, we have successfully established two cell lines in vitro (D10 and D14) from some of these tumors and have chara...

Journal: :Bioorganic & medicinal chemistry 2012
Claire Tacon Eric M Guantai Peter J Smith Kelly Chibale

Herein we report on the semisynthesis and biological evaluation of β-amino alcohol derivatives of the natural product totarol and other simple aromatic systems. All β-amino alcohol derivatives of totarol exhibited higher antiplasmodial activity than totarol [IC(50): 11.69 μM (K1, chloroquine and multi-drug resistant strain), and 11.78 μM (D10, chloroquine sensitive strain)]-12e was the most act...

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