A simplex-centroid design for q mixture components comprises of all possible subsets of the q components, present in equal proportions. The design does not contain full mixture blends except the overall centroid. In real-life situations, all mixture blends comprise of at least a minimum proportion of each component. Here, we introduce simplex-centroid designs which contain complete blend...

Okara, soybean waste from tofu and soymilk production, was utilised as a natural antioxidant in soap formulation for stratum corneum application. D-optimal mixture design was employed to investigate the influence of the main compositions of okara soap containing different fatty acid and oils (virgin coconut oil A (24-28% w/w), olive oil B (15-20% w/w), palm oil C (6-10% w/w), castor oil D (15-2...

The objective of this study was to develop and optimize the gliclazide extended-release formulations by using simultaneously combination of two hydrophilic polymers: HPMC K 15M and sodium alginate as retardant. D-Optimal mixture design was employed to evaluate the effect of HPMC (X(1)), lactose (X(2)), and sodium alginate (X(3)) concentrations on the release rate of gliclazide from the matrices...