A variant of the multidrug-resistant human sarcoma cell line Dx5 was derived by co-selection with doxorubicin and the cyclosporin D analogue PSC 833, a potent inhibitor of the multidrug transporter P-glycoprotein. The variant DxP cells manifest an altered phenotype compared with Dx5, with decreased cross-resistance to Vinca alkaloids and no resistance to dactinomycin. Resistance to doxorubicin ...

The new 4'- hydroxy and 3'- aldehyde phase- 1 metabolites of butobarbitone and pentobarbitone are fully synthesized for the first time. These metabolites were used to idenfity and quantify the natural metabolites in human urine after single and multiple doses of these drugs. The synthesized metobolites have spectral characterizations (IR, NMR, U.V. and mass spectroscopy) consisted with the ...

BACKGROUND Many pharmacologically important peptides are synthesized nonribosomally by multimodular peptide synthetases (NRPSs). These enzyme templates consist of iterated modules that, in their number and organization, determine the primary structure of the corresponding peptide products. At the core of each module is an adenylation domain that recognizes the cognate substrate and activates it...

different medicinal plants have been used in animal and poultry nutrition in last decade. it seems that there are some potential to these medicinal plants to replace with common antibiotics. licorice root (glycyrrhiza glabra) is a medicinal plant that extensively was used in different studies. in the present study, the effect of dietary addition of licorice root on performance and blood energy ...

objective: to study the in vitro color changes of three dental resin veneering materials when immersed in tea, coffee and tamarind extracts. materials and methods: the color changes of heat polymerized tooth colored acrylic resin (stellondetrey, b, f14, dpi dental products of india ltd, mumbai), auto polymerized tooth colored acrylic resin (dpi, b, qv5, dpi dental products of india ltd, mumbai)...

In the last five decades study on plant secondary metabolites have been increasing. Higher plants with a wide range of secondary metabolites have been very important in the search of new therapeutic agents. Flavonoids are most widely distributed secondary natural metabolites that found in plants which occuring in free forms or as glycosides with polyphenolic structure. In this study secondary m...

objective: the growing resistance of different bacteria to antibiotic chemical drugs have become the global issue. this investigation is the first study of the antimicrobial activity of the essential oil of flowering aerial parts of vaccinium arctostaphylos. the current research was conducted to evaluate the antibacterial effects of essential oils and hydroalcoholic extract  extracted from aeri...

background: the knowledge of blood parameters is important for assessing the physiological status and health of animals. objectives: this study was conducted to determine the effect of heavy pregnancy on some serum indices of dromedary camels. methods: twenty clinically healthy female dromedary camels aged between 4-5 years were divided into two equal groups: i: pregnant camels in their last tr...

In the last five decades study on plant secondary metabolites have been increasing. Higher plants with a wide range of secondary metabolites have been very important in the search of new therapeutic agents. Flavonoids are most widely distributed secondary natural metabolites that found in plants which occuring in free forms or as glycosides with polyphenolic structure. In this study secondary m...