New porous double layer (PDL) transpiration cooling technologies can allow gas turbine entry temperatures to be increased beyond current limits towards higher engine efficiency. However, PDL systems require inclined film holes with stress concentration factors in excess of 3.8. Combination thermoelastic Finite Element (FE) analysis Neuber type local strain approaches gives similar cyclic range ...

Corticostriatal synapse plasticity of medium spiny neurons is regulated by glutamate input from the cortex and dopamine input from the substantia nigra. While cortical stimulation alone results in long-term depression (LTD), the combination with dopamine switches LTD to long-term potentiation (LTP), which is known as dopamine-dependent plasticity. LTP is also induced by cortical stimulation in ...

The seismic behavior and plasticity spreading of a neotype column-slab high pier are researched in this paper. Four scale model tests of a web slab with two boundary columns are carried out under cyclic inelastic lateral displacements simulating seismic response. The test results show that the neotype column-slab high pier has strong and stable bearing capacity, good ductility, and energy dissi...

Activation of cyclic AMP dependent kinase is believed to mediate slow onset, long-term potentiation (LTP) in central neurons. Cyclic-AMP activates a cascade of molecular events leading to phosphorylation of the nuclear cAMP responsive element binding protein (pCREB). Whereas a variety of stimuli lead to activation of CREB, the molecular processes downstream of CREB, which may be relevant to neu...

Co-evolutionary algorithms are able to simulate multiple species evolving in a shared environment. Previously, master tournaments have been employed to establish more accurate fitness measurements, in response to the Red Queen Effect. This study proposes to apply a taximetric cluster analysis to master tournament data. This allows to build a hierarchical ‘family’ tree, based on the phenotypes (...

Depression is one of the most common and most devastating psychiatric disorders. Despite its high prevalence and socio-economic impact, little is known about its etiology. Preclinical and clinical studies have demonstrated that depression can lead to cell loss and atrophy in limbic brain structures including hippocampus. An emerging hypothesis suggests that the treatment of depression is likely...

Significant progress has been made toward understanding the mechanisms by which organisms learn from experiences and how those experiences are translated into memories. Advances in molecular, electrophysiological and genetic technologies have permitted great strides in identifying biochemical and structural changes that occur at synapses during processes that are thought to underlie learning an...