Abstract A new series of pyridine-2-one and pyrazole derivatives were designed synthesized based on cyanoacrylamide containing 2,4-dichlro aniline 6-methyl 2-amino pyridine as an aryl group. Condensation 3a–d with different active methylene (malononitrile, ethyl cyanoacetate cyanoacetamide, acetoacetate) in the presence piperidine basic catalyst afforded corresponding pyridinone 4a–c , 5 9 13 ....

Demonstration that I B kinase 2 (IKK-2) plays a pivotal role in the nuclear factorB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment of rheumatoid arthritis. In the present study, we demonstrate that a novel, potent (IC50 17.9 nM), and selective inhibitor of...