The aim of this study is to investigate the ability of intramuscular and intravenous sulfanegen sodium treatment to reverse cyanide effects in a rabbit model as a potential treatment for mass casualty resulting from cyanide exposure. Cyanide poisoning is a serious chemical threat from accidental or intentional exposures. Current cyanide exposure treatments, including direct binding agents, meth...

When cyanide poisoning is treated with a methemoglobin-forming agent, oxidative metabolism is protected at the expense of the oxygen capacity of the blood. The affinity of methemoglobin for CN- is high enough to compete with cytochrome oxidase, which protects the latter from becoming blocked, but all hemoglobin used for this purpose is lost for the transport of oxygen. Therefore, the fractions ...

Smoke inhalation injury is frequently accompanied by cyanide poisoning that may result in substantial morbidity and mortality, and methods are needed to quantitatively determine extent of airway injury. We utilized a 3-D endoscopic frequency-domain optical coherence tomography (FD-OCT) constructed with a swept-source laser to investigate morphological airway changes following smoke and cyanide ...

To determine the lethal effect of cyanide poisoning on the liver cells using ALP, AST, ALT and Bilirubin (Total and Conjugated) as test indicators, eighteen (18) male guinea pigs, age matched were used for this study. This included 12 guinea pigs which served as test groups and injected with different concentrations of potassium cyanide saline solution while 6 guinea pigs without cyanide inject...

Here we report the case of a 70-year-old woman who committed suicide by cyanide poisoning. During resuscitation cares, she underwent an antidote treatment by hydroxocobalamin. Postmortem investigations showed marked bright pink discolouration of organs and fluids, and a lethal cyanide blood concentration of 43 mg/L was detected by toxicological investigation. Discolouration of hypostasis and or...

Cyanide has gained historical notoriety as a poison used with intent to cause fatality. Its occurrence in industry is confined to a small number of uses in a relatively narrow range of industries, including the manufacture of Perspex and nylon and in electroplating. With proper controls in these settings, episodes of poisoning are extremely rare. However, because of the potential for a fatal ou...