نتایج جستجو برای: cuzn superoxide dismutase

تعداد نتایج: 34128  

Journal: :Circulation 2007
Lie Gao Wei Wang Dongmei Liu Irving H Zucker

BACKGROUND In a recent study, we demonstrated that an increase in oxidative stress in the rostral ventrolateral medulla plays a critical role in the sympathoexcitation observed in chronic heart failure (CHF). Growing evidence indicates that exercise training evokes an antioxidative effect in CHF. In the present study, we therefore hypothesized that long-term exercise exerts its beneficial effec...

Journal: :Circulation research 1998
Y Horie R Wolf S C Flores J M McCord C J Epstein D N Granger

The objectives of this study were to (1) determine whether transgenic (Tg) mice overexpressing copper/zinc-superoxide dismutase (CuZn-SOD) are protected from the deleterious effects of gut ischemia/reperfusion (I/R) and (2) compare the effectiveness of Tg SOD overexpression in attenuating I/R injury to intravascularly administered CuZn-SOD or manganese (Mn)-SOD. The accumulation of fluorescentl...

Journal: :Hypertension 2009
Ana M Briones Natalia Rodríguez-Criado Raquel Hernanz Ana B García-Redondo Raul R Rodrigues-Díez María J Alonso Jesús Egido Marta Ruiz-Ortega Mercedes Salaices

Angiotensin II (Ang II) modulates vasomotor tone, cell growth, and extracellular matrix deposition. This study analyzed the effect of atorvastatin in the possible alterations induced by Ang II on structure and mechanics of mesenteric resistance arteries and the signaling mechanisms involved. Wistar rats were infused with Ang II (100 ng/kg per day, SC minipumps, 2 weeks) with or without atorvast...

Journal: :Brain : a journal of neurology 2001
J Jacobsson P A Jonsson P M Andersen L Forsgren S L Marklund

Mutations in CuZn-superoxide dismutase (CuZn-SOD) have been linked to familial amyotrophic lateral sclerosis (ALS), and motor neurone death is caused by the gain of a toxic property of the mutant protein. Here we determined amounts, activity and molecular forms of CuZn-SOD in CSF from ALS patients carrying the D90A and other CuZn-SOD mutations and patients without such mutations. There were no ...

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