PURPOSE To estimate cure rate following graft rejection in bilateral corneal transplants in Iranian patients with keratoconus and to determine risk factors associated with rejection. METHODS In this retrospective study, data were compiled from records of patients who had undergone bilateral penetrating keratoplasty (PK) for keratoconus between 1988 and 2007. In order to estimate cure rate in ...

In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Pa...

We propose a class of Bayesian cure rate models by incorporating a baseline density function as well as multiplicative and additive covariate structures. Our model naturally accommodates zero and non-zero cure rates, which provides an objective way to examine the existence of a survival fraction in the failure time data. An inherent parameter constraint needs to be incorporated into the model f...

BACKGROUND AND OBJECTIVES Coagulase-negative Staphylococcus species is the most common cause of peritoneal dialysis-related peritonitis; however, the optimal treatment strategy of coagulase-negative Staphylococcus species peritonitis remains controversial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS All of the coagulase-negative Staphylococcus species peritonitis in a dialysis unit from 199...

BACKGROUND Viral warts are a common infectious disease and liquid nitrogen cryotherapy is one of the most common methods for treatment of these warts. Hand-foot viral warts frequently recur and reduce quality of life as well. OBJECTIVE To find the ideal treatment interval between cryotherapy sessions that can influence not only the cure rate but also the recurrence rate for hand-foot viral wa...

Cure rate estimation is an important issue in clinical trials for diseases such as lymphoma and breast cancer and mixture models are the main statistical methods. In the last decade, mixture models under different distributions, such as exponential, Weibull, log-normal and Gompertz, have been discussed and used. However, these models involve stronger distributional assumptions than is desirable...

Dr. Raghavan is to be commended for a concise and comprehensive overview of the management of germ cell tumors. As he suggests, given the demographics of this relatively uncommon disease and the high cure rate that can be achieved with proper treatment and follow-up, it behooves us to maintain these excellent results, even while striving to reduce the toxicity of treatment. We will highlight a ...

Due to significant progress in cancer treatments and management in survival studies involving time to relapse (or death), we often need survival models with cured fraction to account for the subjects enjoying prolonged survival. Our article presents a new proportional odds survival models with a cured fraction using a special hierarchical structure of the latent factors activating cure. This ne...

With rapid improvements in medical treatment and health care, many datasets dealing with time to relapse or death now reveal a substantial portion of patients who are cured (i.e., who never experience the event). Extended survival models called cure rate models account for the probability of a subject being cured and can be broadly classified into the classical mixture models of Berkson and Gag...