Turmeric in Latin is Curcuma longa. Turmeric is the yellow spice that gives flavor to curried dishes. In the Far East, Turmeric is valued for more than just its culinary uses. The herb has been employed in the Ayurvedic healing tradition for centuries. The active ingredient in turmeric is the intense yellow pigment that is called curcumin. Curcumin is composed of three curcuminoids and is gener...

BACKGROUND Alzheimer's disease (AD) is the most common type of presenile and senile dementia. The human β-amyloid precursor cleavage enzyme (BACE-1) is a key enzyme responsible for amyloid plaque production, which implicates the progress and symptoms of AD. Here we assessed the anti-BACE-1 and behavioral activities of curcuminoids from rhizomes of Curcuma longa (Zingiberaceae), diarylalkyls cur...

Abstract Curcumin, which is derived from the turmeric rhizomes (curcuma longa) as a natural polyphenol, is a substantially lipophilic molecule. This commonly used substance is employed as a spice and coloring agent in food and contains potent antioxidant, as well as anti-inflammatory, and anti-proliferative tumor activities. The developed nanomicelle formulations of curcumin are used to ...

The dried, ground rhizome of turmeric (Curcuma longa) has been used in Asian medicine for centuries. This perennial plant in the ginger family is cultivated throughout the tropics and is used as both a spice and to support health. Curcumin is a term that is sometimes used to refer to any or all of the curcuminoid compounds in turmeric. There are three main curcuminoids in turmeric, of which cur...

BACKGROUND Few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Success in translating this potential into tangible benefits has been limited by inherently poor intestinal absorption, rapid metabolism, and limited systemic bioavailability. Seeking to ...

Curcumin (diferuloylmethane), a component of turmeric, has been shown to have therapeutic properties. Induction of phase 2 detoxifying enzymes is a potential mechanism through which some of the actions of curcumin could proceed. Heme oxygenase-1 (HO-1), an antioxidant phase 2 enzyme, has been reported to have cytoprotective effects in pancreatic beta-cells. Curcumin on further purification yiel...

BACKGROUND Curcumin is one of the leading compound extracted from the dry powder of Curcuma longa (Zingiberaceae family), which possess several pharmacological properties. However, in vivo administration exhibited limited applications in cancer therapies. RESULTS Twenty-four curcumin derivatives have synthesized, which comprises cyclohexanone 1-10, acetone 11-17 and cyclopentanone 18-24 serie...

Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive properties. Pharmacokinetic and pharmacodynamic parameters have been reported, but few data exist describing whether methodologies are suitably robust for curcuminoid detection in colonic biopsy specimens. Information on the acceptability of prolonged administration of daily curcumin is not available. Thi...

Abstract Cell structure modification techniques have the potential to improve curcuminoid recovery in Curcuma longa . In this study, different pre-treatments such as high hydrostatic pressure (HPP, processing), ultrasound (US), pulsed electric field (PEF), and ohmic heating (OH) were used on dried C. before aqueous extraction at pH 2.0, 5.0, 8.0. The released curcuminoids, cell disintegration i...

In addition to well-known curcuminoids, three colored metabolites were isolated from cultured cell clumps that had been induced from buds on turmeric rhizomes. The isolated compounds were identified as dihydro derivatives of curcuminoids, dihydrocurcumin (dihydroCurc), dihydrodesmethoxycurcumin-a (dihydroDMC-a), and dihydrobisdesmethoxycurcumin (dihydroBDMC). The cell clumps did not contain dih...