Metalloenzymes of the Lineage of Molecular Subclass B1), New Members Flavobacterium odoratum (Formerly Myroides odoratimimus and Myroides odoratus TUS-1 and MUS-1 from-Lactamases β Chromosome-Encoded

A 14.5 GHz ECRIS has been designed and fabricated at KAERI (Korea Atomic Energy Research Institute) to produce multi-charged ion beam (especially for C ion beam) for medical application. The magnet system has cupper conductor solenoid coils and a permanent magnet hexapole. A welded tube with aluminium and stainless steel is used for an ECR plasma chamber to improve the production of secondary e...

Dioxygen activations constitute one of core issues in copper-dependent metalloenzymes. Upon O2 activation, metalloenzymes such as particulate methane monooxygenases (pMMOs), lytic polysaccharide (LPMOs) and binuclear copper enzymes PHM DβM, are able to perform various challenging C–H bond activations. Meanwhile, copper-oxygen containing complexes have been synthetized mimic the active species a...

Natural metalloenzymes are a continuing source of inspiration for the design of bio-inspired catalyst. Key to their high catalytic efficiencies and excellent (enantio)selectivities are the second coordination sphere interactions provided by the protein scaffold. The emerging concept of hybrid catalysis is an effort to impart enzyme-like characteristics to homogeneous transition-metal catalysts ...

Molecular docking uses the three-dimensional structure of a receptor to screen databases of small molecules for potential ligands, often based on energetic complementarity. For many docking scoring functions, which calculate nonbonded interactions, metalloenzymes are challenging because of the partial covalent nature of metal-ligand interactions. To investigate how well molecular docking can id...