When designing drug carriers, the drug-to-carrier ratio is an important consideration, because the use of high quantities of carriers can result in toxicity as a consequence of poor metabolism and elimination of the carriers. However, these issues would be of less concern if both the drug and carrier had therapeutic effects. (-)-Epigallocatechin-3-O-gallate (EGCG), a major ingredient of green t...

PURPOSE The purpose of this study was to assess the improved absorption and in vivo kinetic characteristics of a novel water-in-oil nanoemulsion containing evodiamine-phospholipid nanocomplex (NEEPN) when administered orally. METHODS NEEPN was fabricated by loading an evodiamine-phospholipid nanocomplex into a water-in-oil nanoemulsive system. The gastrointestinal absorption of NEEPN was inve...

Abstract Background Cancer constitutes group of diseases responsible for the second largest cause global death, and it is currently considered one main public health concerns nowadays. Early diagnosis associated with best choice therapeutic strategy, essential to achieve success in cancer treatment. In women, breast most common type, whereas ovarian has highest lethality when compared other neo...

Abstract Background Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and high anticancer potency particular. However, due to its low bioavailability, the difficulty reaching target choosing right dose, there need improve approaches of Ber use therapy. In this study, Ber, noncovalently bound carbon nanostructure C 60 fullerene (C ) at various molar ratios components,...

Overexpression of the human epidermal growth factor receptor (HER) family has been implicated in ovarian cancer because of its participation in signaling pathway regulating cellular proliferation, differentiation, motility, and survival. Currently, effective diagnostic and therapeutic schemes are lacking for treating ovarian cancer, and consequently ovarian cancer has a high mortality rate. Alt...

Abstract Background Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments essentially requires an efficient safe method of delivering into cells while maintaining its stability. Thus, we designed novel synergistic fusion peptides, i.e., SPACE oligoarginine. Results Among peptides siRNAs, n...