نتایج جستجو برای: ctrp 15
تعداد نتایج: 496813 فیلتر نتایج به سال:
The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dos...
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) profiling to identify additional biomarkers of small-molecule sensitivities. We have quantitatively measured the sensitivity of 242 genomically characterized CCLs to an Informer Set of 354 small molecules that target...
Security problems in collaborative work between multiple agencies are less well understood than those in the business and defence worlds. We develop a perspective for policies and models that is task-based on a need-toknow basis. These policies are represented by two protocols, the first CTCP (Collaboration Task-based Creation Protocol) dealing with negotiation, decision and agreement between t...
Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved ...
One artifact from my childhood in the 1960’s that I still remember vividly is the series of plastic slidingblock puzzles manufactured by The Roalex Company of Forest Hills, NY (no relation to the maker of fine timepieces). These consisted of a high-quality plastic puzzle glued to a piece of cardboard containing information about the puzzle. Most of their sixty or so different designs were based...
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