Background: Published papers reported contradictory results about the correlation between bevacizumab effectiveness and primary tumor location of metastatic colorectal cancer (mCRC). Methods: 740 mCRC patients treated with chemotherapy (CT group) and 244 patients treated with bevacizumab plus chemotherapy as first-line setting (CT + B group) were included. Propensity score analyses were used fo...

We investigate the difference between surface matching and target matching for pelvic radiation image guidance. The uniqueness of our study is that all patients have multiple CT-on-rails (CTOR) scans to compare to corresponding AlignRT images. Ten patients receiving pelvic radiation were enrolled in this study. Two simulation CT scans were performed in supine and prone positions for each patien...

From the time CT-scanning was introduced in oil and gas industry, its use could be divided into SCAL routine type applications. The first involves flowing fluids through cores, whereas second scanning, mainly whole their native (preserved or unpreserved) state. For core CT-scanning, there has been a constant shift from qualitative to quantitative analysis. size of cores is ideal for scanning th...

We investigated performance of ultrafast (30 fs –200 fs) laser-based x-ray source as an alternative to a microfocal x-ray tube used in micro-CT systems. A number of solid targets including Ge, Mo, Rh, Ag, Sn, Ba, La, Nd with matching filters was used. We optimized conditions for x-rays generation, measured x-ray spectra and obtained images of small animals using various characteristic x-ray lin...

Manual quantitative analysis of cardiac left ventricular function using multi-slice CT is labor intensive because of the large datasets. We present an automatic, robust and intrinsically three-dimensional segmentation method for cardiac CT images, based on 3D Active Shape Models (ASMs). ASMs describe shape and shape variations over a population as a mean shape and a number of eigenvariations, w...

Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV1). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon ...

The aim of this study is to develop a 3D registration algorithm for positron emission tomography/computed tomography (PET/CT) and magnetic resonance (MR) images acquired from independent PET/CT and MR imaging systems. Combined PET/CT images provide anatomic and functional information, and MR images have high resolution for soft tissue. With the registration technique, the strengths of each moda...

We present an approach to the detection of anatomical landmarks in CT data sets. Our first application is detection of vertebrae and landmarks on vertebrae in 2D slices. The core technique is a feature driven matching of a graph created from one or more vertebrae with unseen data. This is based on an approach that has been successfully applied to face recognition in the past. Keywords— Anatomic...

Combining CT – representing bone structures – and PET – visualizing functional information – reveals many advantages in the area of cancer diagnosis and treatment. Here, fully automatic registration is desired but very time consuming when considering big datasets. We present a technique to register CT and PET datasets based on the ”Mutual Information” criterion. To overcome the speed problem we...