introduction: in some intoxicated patients, cerebrospinal fluid (csf) is examined due to the prolonged loss of consciousness, focal neurologic findings, and fever of unknown origin. we aimed to evaluate the probable relationship between the different toxicity causes and the csf indices in poisoned patients and determine if they could predict the patients’ outcome. methods: all patients who had ...

Retinal detachment in adults with posterior segment coloboma is thought to be rhegmatogenous. Vitrectomy techniques are therefore used therapeutically. There is indirect evidence that subretinal fluid in retinal detachment, associated with optic nerve cavitation, is cerebrospinal fluid (CSF). We report 2 pediatric cases, referred for the management of coloboma-related retinal detachment, that p...

A potential strategy to increase the efficacy of topotecan to treat central nervous system (CNS) malignancies is modulation of the activity of ATP-binding cassette (ABC) transporters at the blood-brain and blood-cerebrospinal fluid barriers to enhance topotecan CNS penetration. This study focused on topotecan penetration into the brain extracellular fluid (ECF) and ventricular cerebrospinal flu...

The effect of cerebrospinal fluid (CSF) osmolarity on the CSF volume has been studied on different CSF/brain tissue contact areas. It has been shown, on anesthetized cats under normal CSF pressure, that the perfusion of CSF system (12.96 μl/min) by hyperosmolar CSF (400 mOsml/l) leads to significantly higher outflow volume (μl/min) during ventriculo-cisternal perfusion (29.36 ± 1.17 and 33.50 ±...

Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored th...

Hydrocephalus is an unbalanced condition between the production and absorption of cerebrospinal fluid (CSF). We reported a child with multiloculated hydrocephalus who developed several complications. Our team was challenged to manage his issues during five years follow up. performed multicystic cerebral shunts despite neuroendoscopic evidence.

VERHEGGEN, I.C.M., W. Freeze, J. de Jong, Jansen, A. Postma, M. van Boxtel, F. Verhey and Backes. The application of contrast-enhanced MRI in the assessment blood-cerebrospinal fluid barrier integrity. Choroid plexus epithelial cells form a that enables active, bidirectional exchange between blood plasma cerebrospinal (CSF), known as blood-CSF (BCSFB). Through its involvement CSF composition, B...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

abstract: herpes simplex encephalitis (hse) is a life threatening outcome of herpes simplex virus (hsv) infection of the central nervous system (cns). hsv accounts for 2-5 percent of all cases of encephalitis. one third of cases occur in those younger than 20 years old and one half in those older than 50 years old. clinical diagnosis is recommended in the encephalopathic, febrile patients with ...

creutzfeldt-jacob disease is a prion disease which has a wide range of clinical presentations. its diagnosis is not simple and clinical manifestation along with eeg, mr imaging findings and cerebrospinal fluid (csf) analysis should be considered for a definite diagnosis. a-50-year-old woman referred with cognitive impairment, myoclonic jerks, mutism and difficulty in swallowing to our clinic. e...