In this work, we focus on the development and application of predictive-based strategies for control of particle size distribution (PSD) in continuous and batch particulate processes described by population balance models (PBMs). The control algorithms are designed on the basis of reduced-order models, utilize measurements of principle moments of the PSD, and are tailored to address different c...

Increasing global competition, volatile markets and the demand for individual products challenge companies in almost all business sectors require innovative solutions. In chemical pharmaceutical industries, these include modular design, integration of several unit operations one apparatus development small-scale, versatile multipurpose plants. An example such a modular, integrated small-scale s...

The optimal batch control of a multidimensional crystallization process is investigated. A high resolution algorithm is used to simulate the multidimensional crystal size distribution under the operations defined by two optimal control trajectories. It is shown that a subtle change in the optimal control objective can have a very large effect on the crystal size and shape distribution of the pr...

The aim of this study was to examine the effect of Takusha (Alismatis rhizoma), a Kampou medicine, on the formation, growth and aggregation of calcium oxalate (CaOx) crystals by a seed crystal system, an undiluted urine system and a continuous flow crystallizer system. In the seed crystal method using a metastable solution, the inhibitory effect on aggregation and growth of CaOx crystals was ca...

We propose a new concept of knowledge management “Knowledge Liquidization and Crystallization”, and a system “Knowledge Nebula Crystallizer” to support the process. Though there are several theories about knowledge creation (Nonaka et al. 1995)(Fischer et al. 2001)(Shneiderman 1998) and a number of companies have realized their importance, most of them face to difficulty of applying them to the...

A simplified, systematic approach to the mathematical simulation of crystallizers is attempted by using the fundamental principles of mass conservation, via a population balance to the solid phase and a solute balance to both solid and liquid phases. A continuous, isothermal and isochoric crystallizer is assumed to be described by the MSMPR model under transient operating conditions with comple...

In order to improve the traditional freezing crystallization process of calcium nitrate in nitric phosphate process, crystal growth experiments by adding Ca(NO3)2·4H2O seeds in supersaturated calcium nitrate solution in a Circulating Fluidized Bed (CFB) crystallizer were carried out on crystal growth kinetics. The results showed that the growth of C...