Background Although ovarian tissue cryopreservation and transplantation is used for fertility preservation in patient undergoing cytotoxic treatments but obtaining good quality oocyte is still a debate. Xenotransplantation has been introduced as a reliable technique for better understanding of the transplantation conditions, but to achieve healthy embryos, the quality of obtained oocytes need t...

Background: The aim of this study was to evaluate the efficacy of a vitrification protocol developed by our group to cryopreserve ovarian tissue. For this, we used ovaries from non-human primates in order to have an animal model close to the clinical setting. Materials and Methods: Ovarian biopsies from five adult baboons were vitrified, warmed and autografted. After five months, follicle survi...

BACKGROUND Cryopreservation is hypothesized to result in apoptosis, contributing to stromal damage and follicle loss in ovarian tissue. This study investigated tissue viability following whole ovine ovary cryopreservation and examined the effects of the anti-apoptotic agent sphingosine-1-phosphate (S-1-P) on ovarian cryopreservation efficiency. METHODS Whole ovine ovaries were cryoperfused an...

PURPOSE Cancer treatments for young women can permanently or temporarily affect fertility. The purpose of this retrospective analysis was to present the clinical experience and ethical considerations of fertility preservation in female oncology patients in a tertiary gynaecological department. METHODS Since 2002, in 37 patients fertility preservation was performed according to an institutiona...

Cancer treatment modalities are increasingly more effective in achieving complete remission and cure. Aggressive chemotherapy and radiotherapy, as well as bone marrow transplantation, results in >90% cure in many cancers of children and young women. As a result of this success however, a new problem has arisen. Many young women survive to live the rest of their lives in menopause, and have no c...

Ovarian tissue banking is a developing technique aimed to preserve fertility in women at risk for premature ovarian failure (1–3). It entails cryopreservation of ovarian tissue with the option of autografting. Reports on the autografting of cryopreserved ovarian cortex segments describe the resumption of steroid production (4), follicle development (5, 6), and (in sheep) model successful pregna...

background: one of the promising methods in fertility preservation among women with cancer is cryopreservation of ovarian cortex but there are many drawbacks such as apoptosis and considerable reduction of follicular density in the transplanted ovary. one solution to reduce ischemic damage is enhancing angiogenesis after transplantation of ovarian cortex tissue. objective: the aim of this study...

current protocols for cancer treatment could lead to the failure of ovarian function and subsequent infertility in women. therefore, utilizing ways to preserve fertility in these individuals seem to be essential. in this review, the full-text of articles which were accessible and had been published during 1976 to 2009 about different methods of female fertility preservation were collected and s...