Japanese cedar pollinosis has been recognized recently as a serious social problem because of its high prevalence in Japan. It is well-known that the pollen grains of Cryptomeria japonica pollen (so-called Japanese cedar pollen) usually exist as coarse particles about 30 μm. However, it was supposed that the major allergen Cry j 1 (Cry j 1 particles) could be released to the atmosphere as respi...

This paper addresses the problem of infants’ cry fundamental frequency estimation. The fundamental frequency is estimated using a modified simple inverse filtering tracking (SIFT) algorithm. The performance of the modified SIFT is studied using a real database of infants’ cry. It is shown that the algorithm is capable of overcoming the problem of under-estimation and over-estimation of the cry ...

Drosophila cryptochrome (CRY) is a key circadian photoreceptor that interacts with the period and timeless proteins (PER and TIM) in a light-dependent manner. We show here that a heat pulse also mediates this interaction, and heat-induced phase shifts are severely reduced in the cryptochrome loss-of-function mutant cry(b). The period mutant per(L) manifests a comparable CRY dependence and drama...

OBJECTIVE To examine the underlying mechanisms of adults' intended caregiving responses to cry sounds in a behavioral genetic design and to investigate the role of cry pitch and perceived urgency in sensitive and harsh caregiving responses. METHODS The sample consisted of 184 adult twin pairs (18-69 years), including males and females, parents and nonparents. In an experimental design we pres...

BACKGROUND Allergen specific immunotherapy is highly effective, but adverse events may occur during treatment. Peptide-based immunotherapy has been proposed as one of new strategies for reduction of allergic adverse reactions. We examined the possibility of candidate peptides for the development of peptide-based immunotherapy for Japanese cedar pollinosis. METHODS Twelve Cry j 1-specific T-ce...

Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and evince hyperactive transcription of Ste in the testes. Ste seems to be the active element in this system, and it has be...

3. The absence of CRY inhibited the per effect on another temperature-centric feature of rhythms, temperature compensation of circadian period. The period of per becomes longer at elevated temperatures, whereas it is essentially unaffected in wild-type flies. We reported that a double mutant strain, expressing PERL and also missing wild-type CRY, recovered normal temperature compensation. In ot...

Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood. Here, we report that KPNB1, an importin β component of the ncRNA repressor of nuclear factor of activated T cells (NRON) ribonucleoprotein complex, mediates nuclear translocation and rep...

Circadian pacemakers are essential to synchronize animal physiology and behavior with the dayrationight cycle. They are self-sustained, but the phase of their oscillations is determined by environmental cues, particularly light intensity and temperature cycles. In Drosophila, light is primarily detected by a dedicated blue-light photoreceptor: CRYPTOCHROME (CRY). Upon light activation, CRY bind...

Cryptochrome (CRY) is the primary photoreceptor of Drosophila's circadian clock. It resets the circadian clock by promoting light-induced degradation of the clock protein Timeless (TIM) in the proteasome. Under constant light, the clock stops because TIM is absent, and the flies become arrhythmic. In addition to TIM degradation, light also induces CRY degradation. This depends on the interactio...