Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder characterized by neuropathic pain associated with local edema and changes suggestive of autonomic involvement such as altered sweating, skin color, and skin temperature of the affected region. CRPS was described associated with several diseases, such as trauma, psychiatric conditions, and cancer. However, no case assoc...

Complex regional pain syndrome (CRPS) is a disorder characterized by an intractable, disabling pain of the affected limb. It is triggered by various injuries and is often resistant to standard therapy. We report a young soldier with CRPS of the right hand sustained from an electrical injury, who had improvement in resting pain with Zoledronic acid. In this report, we discuss the therapeutic opt...

Complex regional pain syndrome (CRPS) represents a state of constant and often disabling pain, affecting one region (usually hand) and often occurs after a trauma whose severity does not correlate with the level of pain. The older term for this condition of chronic pain associated with motor and autonomic symptoms is reflex sympathetic dystrophy or causalgia. The aim of this review, based on co...

ABSTRACT Objective. Complex regional pain syndrome (CRPS) is a severe neuropathic pain state that is oftenObjective. Complex regional pain syndrome (CRPS) is a severe neuropathic pain state that is often disproportionate to the initial trauma. Associated features are autonomic dysregulation, swelling, motor dysfunction, and trophic changes to varying degrees. Despite a multitude of treatment mo...

Complex regional pain syndrome (CRPS) is a painful condition developed after a traumatic injury of extremities. While the pathophysiology of CRPS has not clarified yet, the roles of excessive regional inflammation, peripheral sensitization of primary somatosensory afferents, and central sensitization of spinal neurons associated with the symptoms of this disorder have been intensively investiga...

BACKGROUND The purpose of the present paper was to assess efficiency of treatment and long-term functional outcome of complex regional pain syndromes (CRPS) in children who were treated in the chronic pain clinic at a major tertiary hospital in Israel. METHODS The files of 14 children with CRPS were analyzed retrospectively. Demographic data, initiating event, referring source, time needed fo...

"Pain exposure" physical therapy (PEPT) is a new treatment for patients with complex regional pain syndrome type 1 (CRPS-1) that consists of a progressive-loading exercise program and management of pain-avoidance behavior without the use of specific CRPS-1 medication or analgesics. The aim of this study was to investigate primarily whether PEPT could be applied safely in patients with CRPS-1. T...

The first step in the management of complex regional pain syndrome (CRPS) is coming to the arrival at an accurate diagnosis. CRPS is diagnosed by inclusion and not by exclusion. No laboratory tests can diagnose CRPS 100% of the time. The use of scintigraphic triphasic bone scans (STBS) may help diagnose CRPS in approximately 55% of the cases in the first six months(1). The research of Chelimsky...

Complex regional pain syndrome (CRPS) is a clinical syndrome of pain, autonomic dysfunction, trophic changes, and functional impairment. CRPS is common after hand trauma or surgery. Early diagnosis and intervention is critical for adequate recovery. The diagnosis of CRPS requires a careful history, physical examination, and supporting diagnostic testing. Optimal treatment requires a multidiscip...

Complex regional pain syndrome type I (CRPS-I) is infrequently associated with various malignancies, and may lead to severe pain in already debilitated patients. The causal relationship between CRPS-I and paraneoplastic syndrome, controversies in diagnosis and treatment, and new treatment modalities are presented.