1A microwave (MW)-assisted crosslinking process to prepare hydrogel-forming microneedle (MN) arrays was evaluated. Conventionally, such MN arrays are prepared using processes that includes a thermal crosslinking step. Polymeric MN arrays were prepared using poly(methyl vinyl ether-alt-maleic acid) crosslinked by reaction with poly(ethylene glycol) over 24 h at 80 °C. Polymeric MN arrays were pr...

Antibodies developed during HIV-1 infection lose efficacy as the viral spike mutates. We postulated that anti-HIV-1 antibodies primarily bind monovalently because HIV's low spike density impedes bivalent binding through inter-spike crosslinking, and the spike structure prohibits bivalent binding through intra-spike crosslinking. Monovalent binding reduces avidity and potency, thus expanding the...

Systematically tunable in vitro platforms are invaluable in gaining insight to stem cell-microenvironment interactions in three-dimensional cultures. Utilizing recombinant protein technology, we independently tune hydrogel properties to systematically isolate the effects of matrix crosslinking density on cardiomyocyte differentiation, maturation, and function. We show that contracting human emb...

Purpose The purpose of this study was to characterize the relation between corneal hydration and stiffening effects of the UVA/riboflavin collagen crosslinking treatment and to investigate how artificially swelling the cornea prior to this treatment procedure affects tensile property improvement. Methods Porcine corneas were collagen crosslinked in vitro at different hydration levels using a ...

We investigated the interfacial properties of poly(vinyl alcohol) carrying UV-crosslinkable pendant quaternized stilbazole (styrylpyridinium), PVA-SbQ. The extent and dynamics of PVA-SbQ cyclodimerization reactions and crosslinking induced by UV irradiation were monitored in situ and in real time by quartz crystal microgravimetry (QCM). Sensograms reflecting time-dependent changes in density an...

Ultra-high molecular weight polyethylene (UHMWPE) has been widely used as acetabular cup in total hip replacement (THR) and tibial component in total knee replacement (TKR). Crosslinking of UHMWPE has been successful used to improve its wear performance leading to longer life of orthopedic implants. Crosslinking can be performed by radiation or organic peroxides. Peroxide crosslinking is a conv...

Two grades of metallocene-catalysed LLDPE and one grade of low-density polyethylene (LDPE) have been silane grafted and crosslinked by contact with water and their performance has been compared and evaluated. The effects of vinytrimethoxysilane (VTMOS) levels on the degree of crosslinking for each grade were also studied. It was found that increasing level of silane increases the degree of cros...

to enhance solubility and the performance of a plant gum (from south peach tree of china, sp gum) as a drilling fluid additive, we explored the potential of modified sp (msp) gum by modifying it with epichlorohydrin. the modification conditions, such as the mass ratio of  the crosslinking agent, ph and temperature, were optimized and the results show that 56.40 g/100g mass ratio of the crosslin...