Surface solid dispersions using water-insoluble carriers like crospovidone, croscarmellose sodium, sodium starch glycolate, pre-gelatinized starch, potato starch and Avicel PH 101 were investigated to enhance the dissolution rate of the glimepiride, a poorly water insoluble drug. The effect of various carriers on dissolution profile was studied using presence absence model. The surface solid di...

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol a...

This study was performed to design bilayer floating tablets of simvastatin and lovastatin to give sustained release of simvastatin and immediate release of lovastatin. Bilayer floating tablets comprised of two layers i.e, immediate and sustained release layers. Bilayer floating tablets of simvastatin and lovastatin was formulated by using HPMCK 100M and super disintegrants like sodium alginate,...

The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery drug. Tablet does not only refer to break up interparticle bonds, but also relates liquid absorption and swelling behaviour tablet. This study demonstrates use sessile drop method coupled with image processing models analyse surface kinetics four filler combinations (microcrystalline cellulose (MCC)/mann...