Objective: To evaluate the outcome of COVID-positive orthopaedic injury patients operated as emergency cases regarding overall disease progression, laboratory parameters and fracture healing.
 Study Design: Prospective longitudinal study.
 Place Duration Study: Pak Emirates Military Hospital Rawalpindi Combined Malir Karachi Pakistan, from Apr to Nov 2020.
 Methodology: All with ...

Recent studies suggest an immune modulator role for Creactive protein (CRP). We have tested the effect of CRP in a tumor system designed for study of métastases.Fibrosarcoma T241 was implanted on one hind foot of syngeneic C57BL/6 mice. After 17 days, the tumor-bearing feet were amputated, and i.v. therapy of liposomes containing CRP or control re agents was started. Examination of the lungs o...

The classical cardiovascular risk factors explain only a part of the increased macrovascular disease in subjects with type 2 diabetes (1). Reduction of the elastic properties of the aorta is an early marker of atherosclerosis, and it is diagnosed early in the course of type 2 diabetes (2). The detrimental effects of the classical risk factors on aortic distensibility are well known. However, th...

Familial Mediterranean Fever (FMF) is an autosomal recessive disease (MEFV gene) characterized by recurrent fever and inflammatory serositis. Although majority of patients have random pattern of attacks, some reports described precipitating factors. A literature review indicated that FMF attacks occurring only during menstruation are rarely seen. We report the cases of three patients with sever...

An 11-year-old boy presented in February 2008 with a facial butterfly rash that persisted for at least one month. Lupus erythematosus was repeatedly suspected and the boy was referred for further examinations. A detailed medical history did not reveal any arthralgia, fever, malaise, exanthema, intense exposure to ultraviolet (UV) light in the period one to three weeks before onset of the rash. ...

Rheumatoid arthritis (RA) is a chronic inflammatory disease with uncontrolled damage of synovial tissues. Nearly one percent of world population is known to be affected by RA. Clinical testing and imaging studies of joints help in the diagnosis and monitoring of disease progression. This disease is more prevalent in females but literature lacks the comparative study showing biochemical changes ...

High-sensitivity C-reactive protein is a well-known risk factor for cardiovascular heart diseases. In this study we aimed to determine the levels of serum high-sensitivity Creactive protein in patients with newly diagnosed type diabetes mellitus and impaired fasting glucose, and to obtain clinical results by comparing impaired fasting glucose group with type 2 diabetes mellitus and normal group...

The gene for the prototype acute phase reactant, Creactive protein, has been isolated from two X phage libraries containing inserted human DNA fragments using synthetic oligonucleotide probes. Nucleotide sequence analysis indicates that after coding for a signal peptide of 18 amino acids and the first two amino acids of the mature protein, there is an intron of 278 base pairs followed by the nu...

The effect of human C-reactive protein incorporated into multilamellar vesicles (CRP-MLV) was studied in assays of macro phage function. Peritoneal exÃodate macrophages from C57BL/ 6 mice phagocytosed CRP-MLV in vitro more rapidly than multilamellar vesicles bearing comparable amounts of immunoglobulin G. Exposure of peritoneal exÃodate macrophages in vitro to CRP-MLV resulted in development of...