BACKGROUND/AIMS DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Co-rydalis tuber. The aim of this study was to evaluate the effect of DA-9701 on colorectal distension (CRD)-induced visceral hypersensitivity in a rat model. METHODS Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI) using CRD at 1 week after birth (CI group). At 6...

Performance on multicore processors is determined largely by on-chip cache. Computer architects have conducted numerous studies in the past that vary core count and cache capacity as well as problem size to understand impact on cache behavior. These studies are very costly due to the combinatorial design spaces they must explore. Reuse distance (RD) analysis can help architects explore multicor...

Suppression of reactions to one noxious stimulus by a spatially distant noxious stimulus is termed heterotopic antinociception. In lightly anesthetized rats, a noxious visceral stimulus, colorectal distension (CRD), suppressed motor withdrawals but not blood pressure or heart rate changes evoked by noxious hindpaw heat. Microinjection of muscimol, a GABA(A) receptor agonist, into raphe magnus (...

Chronic Respiratory disease is an economically important disease of chicken caused by Mycoplasma gallisepticum. The present study was carried out to study the incidence and factors affecting the incidence of CRD in poultry flocks under Indian conditions. Incidence during different seasons, among different types and breeds of chicken and among different age groups were studied. The overall incid...

The purpose of the present investigation was to examine, in the primate, the role of the postsynaptic dorsal column (PSDC) system and that of the spinothalamic tract (STT) in viscerosensory processing by comparing the responses of neurons in these pathways to colorectal distension (CRD). Experiments were done on four anesthetized male monkeys (Macaca fascicularis). Extracellular recordings were...

The Frizzled (Fz) receptors contain seven transmembrane helices and an amino-terminal cysteine-rich domain (CRD) that is sufficient and necessary for binding of the ligands, the Wnts. Recent genetic experiments have suggested, however, that the CRD is dispensable for signaling. We engineered fz CRD mutant transgenes and tested them for Wg signaling activity. None of the mutants was functional i...

Lactobacillus species ingestion can decrease autonomic responses and spinal fiber discharge to nociceptive colorectal distension (CRD), even in the absence of inflammation. The present study aimed to determine whether dorsal root ganglion (DRG) somas could be a locus where the antinociceptive probiotic may have an effect. Healthy rats were fed with Lactobacillus reuteri or vehicle control for 9...

on an arbitrary time scale T with supT =∞, subject to the following conditions: (C) t ∈ T and [t,∞)T := {t ∈ T : t ≥ t} is a time scale interval in T; (C) r ∈ Crd( [t,∞)T , (,∞)) and ∫ ∞ t  r(t) t =∞; (C) p,q ∈ Crd( [t,∞)T , [,∞)); (C) ξ , δ ∈ Crd(T,T), limt→∞ ξ (t) = limt→∞ δ(t) = ∞, δ has the inverse function δ– ∈ Crd(T,T), v := δ– ◦ ξ ∈ Crd(T,T), ξ , v ∈ Crd( [t,∞)T , (,∞)),...

26-27% of patients with end stage hip and knee arthritis requiring TJR have chronic renal disease. A multi-center, prospective clinical registry was queried for TJA's from 2006 to 2012, and 74,300 cases were analyzed. Renal impairment was quantified using estimated glomerular filtration rate (eGFR) to stratify each patient by stage of CRD (1-5). There was a significantly greater rate of overall...

Background/Aim: Fetuin-A is a circulating calcium-regulatory glycoprotein that inhibits vascular calcification. In the present study, serum fetuin-A was studied as a novel risk factor for the development of endothelial dysfunction (ED) and hemostatic alteration in patients with chronic renal disease (CRD). Patients and Methods: 15 CRD patients on conservative treatment, 15 end stage renal disea...