aim : the aim of this study was to provide quantitative estimations of the burden of death in term of years of life lost (yll) due to colorectal cancer (crc) in iran and a temporal trend analysis. background : colorectal cancer is the third most common cause of cancer-related deaths in the world. yll is a tool for quantifying the burden of disease according to mortality rates. the aim of this s...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

Objective(s): Ten-eleven translocation (TET) family members have been shown to be involved in the development of many tumors. However, the biological role of the TET family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. Materials and Methods:We measured the expression levels of TET family members in colorectal cancer (CRC) specimens, in the c...

The Cyclic Redundancy Check (CRC) was developed as a checksum algorithm for the detection of data corruption in the process of data transmission or storage. However, in some scenarios there's a CRC given which a set of data is expected to have, so the data itself has to be modi ed (at the end or at some chosen position) in a way that it computes to the given CRC checksum afterwards. We present ...

background colorectal cancer (crc) is the third most common cancer in iran and its early detection is necessary. this study is based on perception of people in the east of iran toward crc screening.   methods in a cross-sectional study, 1060 randomly selected individuals who referred to razavi hospital of mashhad, iran, between september the 1st, 2012 and february the 28th, 2013 as patients or ...

Objective(s): The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Resul...

Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles ...