Objective(s): Ten-eleven translocation (TET) family members have been shown to be involved in the development of many tumors. However, the biological role of the TET family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. Materials and Methods:We measured the expression levels of TET family members in colorectal cancer (CRC) specimens, in the c...

The Cyclic Redundancy Check (CRC) was developed as a checksum algorithm for the detection of data corruption in the process of data transmission or storage. However, in some scenarios there's a CRC given which a set of data is expected to have, so the data itself has to be modi ed (at the end or at some chosen position) in a way that it computes to the given CRC checksum afterwards. We present ...

background colorectal cancer (crc) is the third most common cancer in iran and its early detection is necessary. this study is based on perception of people in the east of iran toward crc screening.   methods in a cross-sectional study, 1060 randomly selected individuals who referred to razavi hospital of mashhad, iran, between september the 1st, 2012 and february the 28th, 2013 as patients or ...

Objective(s): The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Resul...

Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles ...

Background While colorectal cancer (CRC) is one of the most preventable causes of cancer mortality, it is one of the leading causes of cancer death in Canada where CRC screening uptake is suboptimal. Given the increased rate of mortality and morbidity among mental health patients, their condition could be a potential barrier to CRC screening due to greater difficulties in adhering to behaviours...

Colorectal cancer (CRC) is a third most common epithelial carcinoma. CRC is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. The use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...

aim : this study investigated the role of cd86 +237 g/c polymorphism in intensifying the risk of crc development. background : colorectal cancer (crc) is a multi-factorial diseases. genetic background could affect the susceptibility of individuals to crc development. cd86 is a co-stimulatory factor on antigen-presenting cells that plays key roles in several cancer related mechanisms such as aut...