The p21 belongs to the CIP/KIP family of CDK inhibitors involved in cell cycle arrest at specific stages of the cell cycle progression. DNA methylation is the best studied epigenetic mark that have been evidently associated to chromatin condensation, and repression of gene transcription. The CpG island hypermethylation in promoter region of certain genes occurs in cancer cells and affects tumor...

There is a potential for synergy effects in utilizing CO2 both enhanced gas recovery (EGR) and geothermal energy extraction (CO2-plume geothermal, CPG) from natural reservoirs. In this study, we carried out reservoir simulations using TOUGH2 to evaluate the sensitivity of recovery, pressure buildup, power generation performance combined CO2-EGR–CPG system key operational parameters. The paramet...

background the imbalance in the t helper (th) 1/th2 and th1/t regulatory (treg) cells-related immune responses plays a key role in pathogenesis of allergic asthma. objectives the aim of this study was to evaluate the effects of cpg-oligodeoxynucleotide (cpg-odn), monophosphoryl lipid a (mpla) and bacillus calmette-guerin (bcg) on the ratio of th1/th2 and th1/treg cells-related parameters in an ...

This paper presents a study on bioinspired closed-loop Central Pattern Generator (CPG) based control of robot fish for obstacle avoidance and direction tracking. The biomimetic is made rigid head with pair pectoral fins, wire-driven active body covered soft skin, compliant tail. CPG model consists four input parameters: the flapping amplitude, angular velocity, offset, time ratio between beat p...

CpG oligodeoxynucleotides (CpG ODNs) is a widely used immune adjuvant, which could activate various immune responses including antiviral response through interaction with Toll-like receptor 9 (TLR9) in mammals. In the present study, four types of CpG ODN (CpG-A, CpG-B CpG-C, and CpG-P) were synthesized and injected to the shrimp Litopenaeus vannamei in order to evaluate their immune enhancement...

Objective(s): Program death 1 (PD-1)/ program death-ligand 1 (PD-L1) pathways, as the main inhibitory checkpoints, induce immunosuppression in the tumor microenvironment (TME). Despite the importance of inhibitor checkpoint receptor (ICR) blockers, their outcomes have been limited by the low immune response rate and induced acquired resistance. Pre-existing tumor-speci...

We evaluated the innate immune response to various synthetic CpG-containing oligodeoxynucleotides (CpG ODNs) by measuring nitric oxide production in the peripheral blood monocytes from turkey poults. The results indicate that the presence of the CpG dinucleotide in ODNs was a prerequisite for activation of turkey monocytes and induction of nitric oxide (NO) synthesis. CpG motifs and sequence st...

Computerization of Clinical Practice Guidelines (CPG) render them to be executable at the point-of-care. In this paper, we present a knowledge modeling methodology to model the form and function of CPG in terms of a new CPG ontology that supports CPG computerization and execution. We developed a CPG ontology, in OWL using Protégé, to represent both the structural elements and the knowledge obje...