Cyclooxygenases (COXs) are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids (PUFAs) to prostaglandins (PGs) and thromboxanes (TXs). Their main role is to catalyze the transformation of AA into the intermediate PGH2, which is the procursor of a variety of prostanoids (PTS) with diverse and potent biological actions. COXs have ...

Many variables in the social, physical, and biosciences, including neuroscience, are non-normally distributed. To improve the statistical properties of such data, or to allow parametric testing, logarithmic or logit transformations are often used. Box-Cox transformations or ad hoc methods are sometimes used for parameters for which no transformation is known to approximate normality. However, t...

The Box–Cox transformation [1,2] (Box and Cox, 1964; Sakia, 1992) has been regarded as a parametric pre-processing technique aimed at making the distribution of a set of points approximately Gaussian. Since normality represents an assumption underlying many statistical data analysis tools, such technique has been widely applied in different fields of Computer Science. In this paper we will prov...

We propose a new methodology to estimate λ, the parameter of the Box–Cox transformation, as well as an alternative method to determine plausible values for it. The former is accomplished by defining a grid of values for λ and further perform a normality test on the λ-transformed data. The optimum value of λ, say ∗ λ , is such that the p-value from the normality test is the highest. The set of p...

BACKGROUND In a random effects meta-analysis model, true treatment effects for each study are routinely assumed to follow a normal distribution. However, normality is a restrictive assumption and the misspecification of the random effects distribution may result in a misleading estimate of overall mean for the treatment effect, an inappropriate quantification of heterogeneity across studies and...

In predicting a future lifetime based on a sample of past lifetimes, the Box-Cox transformation method provides a simple and unified procedure that is shown in this article to meet or often outperform the corresponding frequentist solution in terms of coverage probability and average length of prediction intervals. Kullback-Leibler information and second-order asymptotic expansion are used to j...

Many of us in the social sciences deal with data that do not conform to assumptions of normality and/or homoscedasticity/homogeneity of variance. Some research has shown that parametric tests (e.g., multiple regression, ANOVA) can be robust to modest violations of these assumptions. Yet the reality is that almost all analyses (even nonparametric tests) benefit from improved the normality of var...

In accelerated life testing, the nominal life time is often related to stress levels by an acceleration equation. Three particular models that have been used frequently in the past are the power law model, the Arrhenius model and the Eyring model. In this paper we suggest choosing a model from a model family which includes the three particular models as special cases. This family is deened by a...

background road traffic accidents and their related deaths have become a major concern, particularly in developing countries. iran has adopted a series of policies and interventions to control the high number of accidents occurring over the past few years. in this study we used a time series model to understand the trend of accidents, and ascertain the viability of applying arima models on data...

K e y w o r d s: Box-Cox transformation, SV model, Bayesian inference.