Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...

Cyclooxygenase isoform-2 (COX-2) and microsomal prostaglandin E(2) synthase-1 (mPGES-1) are inducible enzymes that become up-regulated in inflammation and some cancers. It has been demonstrated that their coupling reaction of converting arachidonic acid (AA) into prostaglandin (PG) E(2) (PGE(2)) is responsible for inflammation and cancers. Understanding their coupling reactions at the molecular...

Cyclooxygenase-2 (COX-2) enzyme has been involved in the tumorigenesis and in the progression of colorectal cancer (CRC). The use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs) or selective COX-2 inhibitors has been proposed for the prevention and the treatment of this relevant neoplastic disease. In the light of an innovative alternative to these pharmacological approaches, we re...

background: in this study, the bystander effect of radiation was evaluated on the regulation of cox-2, inos, and 8-ohdg in the lung tissues of sprague-dawley rats with and without pre-administration of melatonin. materials and methods: a 2×2 cm area of the pelvis of male sprague-dawley rats with and without pre-administration of melatonin (100 mg/kg) by oral and ip injection was irradiated with...

Cyclooxygenase-2 (COX-2) fluorescent probes are promising tools for early diagnosis of cancer. Traditionally, COX-2 were designed by connecting two parts, a fluorophore and binding unit, via flexible linker. Herein, new class COX-2-specific have been developed one-step modification from rofecoxib an integrative approach to combine the unit into one. Among them, several analogues not only exhibi...

Inflammation is involved in several stages of diseases such as cardiovascular diseases, asthma, diabetes, neurodegenerative or cancer. Cyclooxygenase-2 (COX-2) an important enzyme that catalyzes the production prostaglandins from arachidonic acid and has role various inflammatory-related pathologies. The selective suppression COX-2 over COX-1 thought to be a useful approach for treating inflamm...