BackgroundEpileptic (absence) seizures in the cerebral cortex can be stopped by pharmacological and optogenetic stimulation of cerebellar nuclei (CN) neurons that innervate thalamus. However, it is unclear how such modify underlying thalamo-cortical oscillations.HypothesisHere we tested whether rhythmic synchronized activity during absence desynchronized single-pulse CN to stop seizure activity...

During navigation, animals integrate sensory information with body movements to guide actions. The impact of both navigational and movement-related signals on cortical visual processing remains largely unknown. We review recent studies in awake rodents that have revealed navigation-related the primary cortex (V1) including speed, distance travelled head-orienting movements. Both subcortical inp...

Over the past decade there has been a growing interest in development of parallel hardware systems for simulating large-scale networks spiking neurons. Compared to other highly-parallel systems, GPU-accelerated solutions have advantage relatively low cost and great versatility, thanks also possibility using CUDA-C/C++ programming languages. NeuronGPU is GPU library simulations neural network mo...

We study the learning dynamics and representations emerging in recurrent neural networks (RNNs) trained to integrate one or multiple temporal signals. Combining analytical numerical investigations, we characterize conditions under which an RNN with n neurons learns D(?n) scalar signals of arbitrary duration. show, for linear, ReLU, sigmoidal neurons, that internal state lives close a D-dimensio...

To study the interactions between thalamic and cortical inputs onto neocortical neurons, we used paired-pulse stimulation (PPS) of thalamic and cortical inputs as well as PPS of two cortical or two thalamic inputs that converged, at different time intervals, onto intracellularly recorded cortical and thalamocortical neurons in anesthetized cats. PPS of homosynaptic cortico-cortical pathways pro...

Abstract Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such bipolar disorder and major depressive disorder. cross the blood-brain barrier reach brain parenchyma within few hours after oral application, however, how lithium influences directly human neuronal function is unknown. We applied patch–clamp microelectrode array te...