Synaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific binding site for certain antiepileptics and is implicated in the treatment of epilepsy. Here, to elucidate the role of SV2A in modulating epileptogenesis, we generated a novel rat model (Sv2a(L174Q) rat) carrying a Sv2a-t...

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

OBJECTIVE At present, there are many antiepileptic drugs with a wide range of side effects on the human body. It was assumed that Zataria multiflora Boiss (Z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. The aim of the present study was to elucidate the effect of Z. multiflora hydroalcoholic extract and its fraction extr...

Introduction: Recently, herbal medicine is widely used as an alternative and complementary therapy in several neurological disorders such as epilepsy. The anti-inflammatory and neuroprotective effects of Zingiber officinale or ginger have been well-documented. The present study was designed to evaluate the effects of ginger extract pre-treatment on seizures behavior, neuronal density and as...

Objective: The most common type of epilepsy affecting about 50 million people worldwide is temporal lobe (TLE). Chemical and electrical kindling methods in animals can be used to form TLE model. In the present study, it was aimed investigate neurogenesis hippocampus adult kindled Wistar rats genetic absence from Strasbourg (GAERS) by immunofluorescence methods.
 
 Methods: Adult GAERS...

introduction: in the kindling-induced seizure model, low and repeated electrical or chemical stimulations, can elevate the neural network excitability and induce epileptiform seizures. opioid receptors are widely distributed in different areas of the brain. on the other hand, morphine has paradoxical effects and induces elevation or alleviation of the pain sensation and excitability, at differe...

Epilepsy affects 1% of the global population, with around 2.4 million new diagnoses annually. Approximately 80% individuals epilepsy reside in low- and middle-income countries, a prevalence 8.2 per 1000 sub-Saharan Africa 8 Nigeria. This study evaluated anticonvulsant properties methanol leaf extract Opilia celtidifolia (MEC) mice chicks. The median lethal dose (LD50) was determined acute MEC w...

INTRODUCTION Considering the prevalence of epilepsy and the failure of available treatments for many epileptic patients, finding more effective drugs in the treatment of epilepsy seems necessary. Oxidative stress has a special role in the pathogenesis of epileptic syndrome. Therefore, in the present study, we have examined the anti-epileptic and anti-oxidant properties of the Ferula Assa Foetid...

BACKGROUND AND PURPOSE This study aimed to investigate the effect of ceftriaxone on oxidative stress and gap junction protein (connexin 43, Cx-43) expression in pentylenetetrazole (PTZ) induced kindling model. METHODS Twenty four Sprague dawely rats were divided into 3 equal groups (a) normal group: normal rats. (b) PTZ kindled group: received PTZ at the dose of 50 mg/kg via intraperitoneal i...