The behavior in mitotic recombination clones of 10 new EMS-induced morphogenetic mutations has been studied in several imaginal systems: wing, eye, and abdominal histoblasts. They have been classified into three major groups according to their phenotypes: Group I is composed of four mutations that cause the disappearance of the mutant cells late in the development of all of the imaginal systems...

Regeneration of an imaginal disc involves highly ordered proliferation and pattern regulation of the newly formed tissue. Although the general principles of imaginal disc regeneration have been extensively studied, knowledge of the underlying molecular mechanisms is far from complete. Results from other model organisms suggest that regeneration is the result of local recapitulation of the norma...

BACKGROUND Class I(A) phosphoinositide 3-kinases (PI 3-kinases) have been implicated in the regulation of several cellular processes including cell division, cell survival and protein synthesis. The size of Drosophila imaginal discs (epithelial structures that give rise to adult organs) is maintained by factors that can compensate for experimentally induced changes in these PI 3-kinase-regulate...

Ance is a single domain homologue of mammalian angiotensin-converting enzyme (ACE) and is important for normal development and reproduction in Drosophila melanogaster. Mammalian ACE is responsible for the synthesis of angiotensin II and the inactivation of bradykinin and N -acetyl-Ser-Asp-Lys-Pro, but the absence of similar peptide hormones in insects suggests novel functions for Ance. We now p...

extractcontinuing education is not new for us because there  is emphasis on learning and continuing education  in our culture including literature, religion, and special  traditions in different ways  .as prophet muhammad (pbuh) says: “seek knowledge from the cradle to the grave” that  it is emphasis on continuous learning and continuous. in the holy quran  the word of “alam “repeatedly stated ...

A Drosophila strain was isolated that carries a lacZ-bearing recombinant P element integrated in the cubitus interruptus Dominant (ci-D) locus. This strain expresses beta-galactosidase in the anterior compartments of embryos and imaginal discs, suggesting that expression of ci-D is anterior-compartment specific. DNA from ci-D was cloned. In situ hybridization to imaginal discs confirmed that ci...

An information processing investigation was performed to quantify the Chevreul pendulum effect: the tendency of a small pendulum, when suspended from the hand and imaginatively concentrated on, to oscillate seemingly of its own accord. Using a time exposure photographic measurement technique, electronically automated visual and auditory imaginal prompts were presented to the subject during imag...

Drosophila melanogaster has been widely used as a model of human Mendelian disease, but its value in modeling complex disease has received little attention. Fly models of complex disease would enable high-resolution mapping of disease-modifying loci and the identification of novel targets for therapeutic intervention. Here, we describe a fly model of permanent neonatal diabetes mellitus and exp...

Imaginal exposure is closely associated with hippocampal processing of traumatic memory. The hippocampus is a target for glucocorticoids which influence memory retrieval and stress response. Glucocorticoid secretion in response to imaginal exposure has not been investigated. We measured subjective distress and salivary cortisol during the 1 and the 20 exposure session in a patient with PTSD. De...

Mass-isolated Drosophila imaginal discs cultured in vitro undergo morphogenesis (evagination) in response to the insect steroid hormone 20-hydroxyecdysone. In vitro translation of mRNA isolated from evaginating discs shows accumulation of at least five new mRNA transcripts that are present only in membrane-bound polysomal RNA and presumably encode imaginal disc membrane or secreted proteins. Us...