Arise, awake, and stop not till the goal is reached e Katha Upanishad, chapter 1.3.14 Every journey starts with a small step forward, and every step in it carries a dream along. The initial steps in this journal's odyssey were by the founder editor, Prof: Johnson Francis, and he carried it as a dream formany years of this journey. Many joined him, nurtured the journal well and helped it grow up...

As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

In the 6th Century BCE the Chinese philosopher Laozi (Lao Tzu) wrote in the Daodejing (Tao Te Ching), “A journey of a thousand miles begins with a single step.” The first step of the journey upon which Pulmonary Circulation is now embarked was taken this past March, with the publication of Volume 1, Number 1, and the present issue is our second step. Where will this journey lead? Inevitably, as...