Hemoglobin Constant Spring (HbCS) is the most common nondeletional alpha-thalassemic mutation and is an important cause of HbH-like disease in Southeast Asia. HbCS variants have an almost normal mean cell volume (MCV) and the anemia is more severe when compared with other alpha-thalassemic variants. We explored the pathobiology of HbCS red blood cells (RBCs) because the underlying cause(s) of t...

An optical trap was used to measure the relationship between restoring force and displacement of a 1.26 μm polystyrene microsphere attached to a 3.5 kilobase-pair DNA strand. Fitting to a wormlike chain model, the persistence length of the DNA molecule was measured as 53.0± 11.6 nm, and the contour length was measured as 713 ± 36 nm. The Hookean spring constant of DNA, at small displacements, w...

The elongated alpha-globin chains of hemoglobin Constant Spring (alpha cs chain of HbCS ) are produced in low amounts such that the alpha cs-gene acts as a form of alpha-thalassemia; yet in the homozygous state the pathophysiological effects of this mutant are more severe than in the corresponding conditions that result from alpha-globin gene deletions. In studies designed to examine this discr...

Here, • m > 0 is the mass. • k > 0 is the spring constant and the spring force −ku(t) is modeled to be proportional to u(t) (i.e. Hooke’s law). The minus sign shows that it is always a restoring force which pulls the mass back towards the equilibrium. • γ ≥ 0 is the damping constant. The damping force may come from the medium (e.g. air, water, or honey), the spring or other sources. It has a mi...

in this paper, the nonlinear conjugate map based on the conjugate hasofer-lind and rackwitz- fiessler (chl-rf) method is applied to evaluate the reliability index using first order reliability method of the embedded noanocompsite beam, which is made from polymer reinforced with carbon nanotubs (cnts). the structure is simulated with timoshenko beam model. the mori-tanaka model is applied for ca...

Determination of density of liquid Springs have wide applications in physics and engineering. In physics laboratories, the students are often asked to find out the value of the spring constant of a given spring. The method generally they follow is based on Hooke’s law. This law states that the extension (x) of a spring within its elastic limit is directly proportional to the force applied to it...

We observe parametric amplification in a torsional micron-scale mechanical resonator. An applied voltage is used to make a dynamic change to the torsional spring constant. Oscillating the spring constant at twice the resonant frequency results in a phase dependent amplification of the resonant motion. Our results agree well with the theory of parametric amplification. By taking swept frequency ...

We present a feedforward control for spring-legged systems in uneven terrain which keeps the running speed constant. The control uses the unique transformation between ground level and flight time to automatically adapt the system parameters during flight to the actual ground level without having to detect it. We further demonstrate how this control for constant speed running can simultaneously...

Haemoglobin (Hb) Adana (HBA2:c.179>A) interacts with deletional and nondeletional α-thalassaemia mutations to produce HbH disorders with varying clinical manifestations from asymptomatic to severe anaemia with significant hepatosplenomegaly. Hb Adana carriers are generally asymptomatic and haemoglobin subtyping is unable to detect this highly unstable α-haemoglobin variant. This study identifie...