STUDY DESIGN A biomechanical study using a cadaver model was conducted to define the function of the nuchal ligament in the restraint of flexion of the cervical spine. OBJECTIVE To test the hypothesis that surgical resection of the nuchal ligament significantly reduces the structural restraints to cervical flexion. SUMMARY OF BACKGROUND DATA Although previous studies have examined the role ...

Cell mechanical properties on a whole cell basis have been widely studied, whereas local intracellular variations have been less well characterized and are poorly understood. To fill this gap, here we provide detailed intracellular maps of regional cytoskeleton (CSK) stiffness, loss tangent, and rate of structural rearrangements, as well as their relationships to the underlying regional F-actin...

Small-distortion constitutive laws are often extemporaneously generalized to large deformations by merely applying them in the unrotated material frame or, equivalently, by using polar rates. This approach does render the resulting constitutive model indifferent to large superimposed rigid rotations, but it may lead to incorrect predictions for both the magnitude and direction of stress wheneve...

We present a simple method to determine the persistence length of short submicrometer microtubule ends from their stochastic trajectories on kinesin-coated surfaces. The tangent angle of a microtubule trajectory is similar to a random walk, which is solely determined by the stiffness of the leading tip and the velocity of the microtubule. We demonstrate that even a single-microtubule trajectory...

Abstract This contribution presents a proper generalized decomposition-based nonlinear solver for an efficient solution of geometrically dynamic problems. The is built as sum dyadic products space and time modes, this so-called enrichments truncated when the required accuracy achieved. In proposed algorithm, we apply consistent linearization residual vectors around currently known over whole sp...

Polyphosphate (polyP) binds to fibrin(ogen) and alters fibrin structure, generating a heterogeneous network composed of 'knots' interspersed by large pores. Here we show platelet-derived polyP elicits similar structural changes in fibrin and examine the mechanism by which polyP alters fibrin structure. Polymerisation of fibrinogen with thrombin and CaCl2 was studied using spinning disk confocal...

We apply a nonlinear-nonlocal field theory for numerical calculation of quasistatic fracture. The model is given by regularized nonlinear pairwise potential in peridynamic formulation. function an explicit formula with first and second derivatives. This fact allows us to write the entries tangent stiffness matrix explicitly thereby saving computational costs during assembly matrix. validate our...